Molecular Mechanisms of B Cell Antigen Gathering and Endocytosis

Current Topics in Microbiology and Immunology
Robbert Hoogeboom, Pavel Tolar

Abstract

Generation of high-affinity, protective antibodies requires B cell receptor (BCR) signaling, as well as antigen internalization and presentation to helper T cells. B cell antigen internalization is initiated by antigen capture, either from solution or from immune synapses formed on the surface of antigen-presenting cells, and proceeds via clathrin-dependent endocytosis and intracellular routing to late endosomes. Although the components of this pathway are still being discovered, it has become clear that antigen internalization is actively regulated by BCR signaling at multiple steps and, vice versa, that localization of the BCR along the endocytic pathway modulates signaling. Accordingly, defects in BCR internalization or trafficking contribute to enhanced B cell activation in models of autoimmune diseases and in B cell lymphomas. In this review, we discuss how BCR signaling complexes regulate each of the steps of this endocytic process and why defects along this pathway manifest as hyperactive B cell responses in vivo.

Citations

Apr 2, 2019·Frontiers in Immunology·Niels J M VerstegenS Marieke van Ham
Mar 16, 2019·Frontiers in Immunology·Jorge Ibañez-VegaMaria-Isabel Yuseff
Feb 28, 2020·Biochemistry Research International·Wanqiong Yuan, Chunli Song
Jul 2, 2021·Frontiers in Cell and Developmental Biology·Yanan LiWenxia Song

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