Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules.

Nature Reviews. Immunology
Geneviève de Saint BasileAlain Fischer

Abstract

Cytotoxic T cells and natural killer cells are crucial for immune surveillance against virus-infected cells and tumour cells. Molecular studies of individuals with inherited defects that impair lymphocyte cytotoxic function have also highlighted the importance of cytotoxicity in the regulation and termination of immune responses. As discussed in this Review, characterization of these defects has contributed to our understanding of the key steps that are required for the maturation of cytotoxic granules and the secretion of their contents at the immunological synapse during target cell killing. This has revealed a marked similarity between cytotoxic granule exocytosis at the immunological synapse and synaptic vesicle exocytosis at the neurological synapse. We explore the possibility that comparison of these two kinetically and spatially regulated secretory pathways will provide clues to uncover additional effectors that regulate the cytotoxic function of lymphocytes.

References

May 1, 1991·The Journal of Experimental Medicine·P J PetersH J Geuze
Mar 3, 1997·The EMBO Journal·E C Dell'AngelicaJ S Bonifacino
Apr 7, 1998·Cell·T WeberJ E Rothman
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·A MüllbacherM M Simon
May 2, 2000·The Journal of Biological Chemistry·K RientoV M Olkkonen
Jun 3, 2000·Nature Genetics·G MénaschéG de Saint Basile
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·S M WilsonN A Jenkins
Mar 27, 2001·The Journal of Cell Biology·J C StinchcombeG M Griffiths
Mar 27, 2001·The Journal of Cell Biology·E K HaddadP A Henkart
Mar 27, 2001·The Journal of Cell Biology·P BahadoranR Ballotti
Sep 7, 2001·Current Opinion in Immunology·G de Saint Basile, A Fischer
Oct 5, 2001·Nature Reviews. Molecular Cell Biology·J Gruenberg
Nov 8, 2001·Journal of Molecular Biology·J B Pereira-Leal, M C Seabra
Feb 12, 2002·Nature Reviews. Molecular Cell Biology·Emma J Blott, Gillian M Griffiths
Feb 23, 2002·Science·Kyeong-Hee LeeAndrey S Shaw
Mar 12, 2002·Nature Cell Biology·Xufeng S WuJohn A Hammer
Mar 22, 2002·Nature Reviews. Immunology·W R Heath, F R Carbone
Jul 12, 2002·Cell·Masaki FukataKozo Kaibuchi
Aug 3, 2002·Nature Reviews. Neuroscience·Josep Rizo, Thomas C Südhof
Nov 28, 2002·Pigment Cell Research·Marjan HuizingWilliam A Gahl
Feb 4, 2003·Nature Reviews. Molecular Cell Biology·Eckart D GundelfingerBritta Qualmann
Apr 2, 2003·Trends in Cell Biology·Ruud F G Toonen, Matthijs Verhage
Jun 6, 2003·Current Opinion in Immunology·Frédéric Rieux-LaucatFrançoise Le Deist
Aug 6, 2003·The Journal of Cell Biology·Kristi G BacheHarald Stenmark
Nov 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Mustapha FaroudiSalvatore Valitutti
Mar 30, 2004·Nature Immunology·Marco A PurbhooMark M Davis

❮ Previous
Next ❯

Citations

Nov 8, 2011·Immunologic Research·Nadia Anikeeva, Yuri Sykulev
Jul 3, 2013·Experimental Cell Research·Konrad Krzewski, Andrew R Cullinane
Dec 12, 2012·Bone Marrow Transplantation·L WangA Janin
Apr 13, 2011·Immunology and Cell Biology·Dongfang LiuEric O Long
Feb 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Andrea Maul-PavicicStephan Ehl
Mar 29, 2013·Proceedings of the National Academy of Sciences of the United States of America·Florie BertrandSalvatore Valitutti
Dec 3, 2011·Science Translational Medicine·Seema ShafiAdrian Hayday
May 9, 2012·Molecular and Cellular Biology·Chih-wen Ou-YangWeiguo Zhang
Apr 2, 2011·Journal of Innate Immunity·Yenan T BrycesonStephanie M Wood
Dec 10, 2013·Hematology·Gritta E Janka, Kai Lehmberg
Jun 12, 2012·Arthritis Research & Therapy·Sebastian Fn BodeStephan Ehl
Mar 28, 2013·International Journal of Medical Sciences·Bin JiangYan-gao Man
Mar 7, 2014·Seminars in Immunology·Frank CichockiYenan T Bryceson
May 6, 2014·Blood Reviews·Gritta E Janka, Kai Lehmberg
Jun 21, 2014·Developmental and Comparative Immunology·Tai-yang MaWen-sheng Li
Jan 18, 2012·Annual Review of Medicine·G E Janka
May 16, 2014·Clinical Immunology : the Official Journal of the Clinical Immunology Society·L AlsinaM Martinez-Gallo
Mar 23, 2013·Annual Review of Immunology·Eric O LongSumati Rajagopalan
Oct 13, 2011·Cellular and Molecular Life Sciences : CMLS·Elena SieniMaurizio Aricò
Jun 9, 2015·Clinical and Experimental Dermatology·J M FawcettC T C Kennedy
Feb 10, 2016·Frontiers in Immunology·Florence NiedergangAndrés Alcover
Sep 24, 2015·Journal of Thrombosis and Haemostasis : JTH·H Heijnen, P van der Sluijs
Apr 3, 2012·Joint, Bone, Spine : Revue Du Rhumatisme·Claire Larroche
Dec 4, 2010·European Journal of Cell Biology·Marcus LettauOttmar Janssen
Mar 5, 2016·Nature Communications·Roxana KhazenSalvatore Valitutti
Jan 13, 2016·The FEBS Journal·Vivien R SuttonJoseph A Trapani
Nov 26, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Matthias Voss, Yenan T Bryceson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.