Molecular mechanisms of bone formation in spondyloarthritis

Joint, Bone, Spine : Revue Du Rhumatisme
Susana Aideé González-ChávezCésar Pacheco-Tena

Abstract

Spondyloarthritis comprise a group of inflammatory rheumatic diseases characterized by its association to HLA-B27 and the presence of arthritis and enthesitis. The pathogenesis involves both an inflammatory process and new bone formation, which eventually lead to ankylosis of the spine. To date, the intrinsic mechanisms of the pathogenic process have not been fully elucidated, and our progress is remarkable in the identification of therapeutic targets to achieve the control of the inflammatory process, yet our ability to inhibit the excessive bone formation is still insufficient. The study of new bone formation in spondyloarthritis has been mostly conducted in animal models of the disease and only few experiments have been done using human biopsies. The deregulation and overexpression of molecules involved in the osteogenesis process have been observed in bone cells, mesenchymal cells, and fibroblasts. The signaling associated to the excessive bone formation is congruent with those involved in the physiological processes of bone remodeling. Bone morphogenetic proteins and Wnt pathways have been found deregulated in this disease; however, the cause for uncontrolled stimulation remains unknown. Mechanical stress appears to play a...Continue Reading

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Citations

Nov 2, 2017·Calcified Tissue International·Margot Van MechelenRik Lories
Aug 30, 2017·Scandinavian Journal of Pain·Brooke NaylorSylvia Maria Gustin
Mar 5, 2020·Expert Opinion on Biological Therapy·Maurizio RossiniAnnamaria Iagnocco
Apr 28, 2021·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Celia María Quiñonez-FloresSusana Aideé González-Chávez

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