Molecular mechanisms of curcumins suppressing effects on tumorigenesis, angiogenesis and metastasis, focusing on NF-κB pathway

Cytokine & Growth Factor Reviews
Yunes PanahiBehrang Shiri Varnamkhasti

Abstract

NF-κB pathway has long been considered as one of the potent prototypical pro-inflammatory signaling pathway and its role in several aspects of human health has been established. Recent studies have suggested that NF-κB activation is the master key in early development and pathobiology of several Cancers. Curcumin is a polyphenolic phytochemical compound with several stablished anti-inflammatory properties and is known to exert its anti-inflammatory effects mostly by interrupting NF-κB signaling pathway at multiple stages. Here we tried to provide a summary of recent finding, focusing on introducing NF-κB signaling pathways and its potential mechanism involved in development of several types of Cancers.

References

Jan 3, 1991·The New England Journal of Medicine·N WeidnerJ Folkman
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·L OsbornG J Nabel
Jan 1, 1994·Critical Reviews in Biochemistry and Molecular Biology·S S Twining
Oct 21, 1996·International Journal of Cancer. Journal International Du Cancer·R B MyersW E Grizzle
May 4, 1999·The Journal of Clinical Investigation·W G Stetler-Stevenson
Dec 22, 1999·Oncogene·M Barkett, T D Gilmore
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Jan 9, 2001·The Journal of Investigative Dermatology. Symposium Proceedings·R Klafter, J L Arbiser
Feb 13, 2001·The Journal of Clinical Investigation·A S Baldwin
Mar 7, 2001·Lancet·F Balkwill, A Mantovani
Nov 20, 2001·Molecular and Cellular Biology·S D WesterheideA S Baldwin
Oct 3, 2002·Nature Reviews. Immunology·Qiutang Li, Inder M Verma
Oct 3, 2002·Nature Reviews. Immunology·Hergen Spits
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Jul 19, 2003·Genes & Development·Casey J FoxCraig B Thompson
Dec 26, 2003·Nature·Honglin ZhouVishva M Dixit
Apr 23, 2004·Trends in Cell Biology·Neil D Perkins
Jul 17, 2004·Carcinogenesis·Gavin P Collett, Frederick Charles Campbell
Aug 3, 2004·Nature Reviews. Immunology·Jukka Vakkila, Michael T Lotze
Aug 26, 2004·Molecular Cell·Atsuhiro KanayamaZhijian J Chen
Aug 27, 2004·Nature·Eli PikarskyYinon Ben-Neriah
Oct 16, 2004·Immunity·Jay K Kolls, Anders Lindén
Jan 20, 2005·The Journal of Experimental Medicine·Claire L LangrishDaniel J Cua
Feb 23, 2005·Current Pharmaceutical Design·M S FurnessJ P Bowen
Aug 2, 2005·Nature Cell Biology·Zhijian J Chen
Oct 6, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Maria M LoTempioMarilene B Wang
Dec 22, 2005·Nature Immunology·Charles N Serhan, John Savill
Dec 27, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Roberto BiancoGiampaolo Tortora

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Citations

Jun 28, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Behrad DarvishiKeivan Majidzadeh-A
Jun 19, 2018·Journal of Cellular and Molecular Medicine·Dimitra P VageliClarence T Sasaki
Mar 16, 2017·Scientific Reports·Jürgen BrückKamran Ghoreschi
Nov 20, 2019·Anti-cancer Drugs·Minghua BaiSuxia Han
Jul 22, 2020·Journal of Cellular and Molecular Medicine·Sotirios G DoukasDimitra Vageli
Jul 4, 2018·International Journal of Molecular Sciences·Felipe Teixeira LimaMozart Marins
Feb 20, 2020·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Naizhi WangQin Liu

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