PMID: 9524805Apr 3, 1998Paper

Molecular mechanisms of developmental disorders

Development and Psychopathology
M Brodsky, P J Lombroso

Abstract

One of the central tenets of developmental psychopathology is the belief that we can learn more about normal functioning through the study of psychopathology and arrive at a better understanding of pathological conditions through investigations of normal behavior. Advances in knowledge from one area will inform us regarding mechanisms at work in the other. A similar perspective is the driving force behind recent scientific advances in our understanding of certain developmental disorders. In this paper, molecular findings for four developmental disorders are reviewed: Prader-Willi syndrome, fragile X syndrome, Williams syndrome, and lissencephaly. These disorders were chosen for discussion because putative genes for each of them have been isolated. The ways in which mutations within these genes disrupt normal cognitive and behavioral functioning are discussed. Although considerable progress has been achieved in understanding the genetic mechanisms for these illnesses, much more research is needed to identify the environmental and genetic factors that interact to contribute to the expression of the more complex behavioral disorders.

Citations

Aug 12, 2000·Journal of the American Academy of Child and Adolescent Psychiatry·M W StateJ F Leckman
Nov 27, 2002·Mental Retardation·Steven F Warren
May 12, 2009·Neuropsychologia·Amy M SpilkinDoris A Trauner
Mar 12, 2019·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Chenglong SunSøren R Paludan
Mar 10, 2001·Mental Retardation and Developmental Disabilities Research Reviews·L AbbedutoT Dolan
Dec 22, 2004·Mental Retardation and Developmental Disabilities Research Reviews·Leonard Abbeduto, Donna Boudreau

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