Molecular mechanisms of dietary restriction in aging-insights from Caenorhabditis elegans research

Science China. Life Sciences
JianFeng LanDi Chen

Abstract

Dietary restriction (DR) is one of the most robust environmental manipulations that not only extend life span but also delay the onset of age-related diseases in almost every species examined. Caenorhabditis elegans plays an important role in aging studies due to its simple life cycle, easy genetic manipulations and highly conserved genome. Recent studies have demonstrated that the beneficial effects of DR are mediated by the highly conserved transcription factors and signaling pathways in C. elegans. Here we review recent progress in the methodology and molecular mechanisms of DR using C. elegans as a model, as well as prospects for future research.

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Citations

Apr 12, 2015·Science China. Life Sciences·Xiang Gao
Oct 21, 2015·Experimental Gerontology·Neda Nasiri MoghadamVolker Loeschcke

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