PMID: 11604564Oct 18, 2001Paper

Molecular mechanisms of drug-induced thrombocytopenia

Current Opinion in Hematology
J K Burgess

Abstract

A wide range of drugs can induce thrombocytopenia. Molecular mechanisms for the formation of specific epitopes for all the drug-dependent antibodies appear to be very similar. A restricted set of glycoproteins on the platelet surface interacts with the drugs to form neoepitopes, to which the drug-dependent antibodies bind. Molecular mapping of antigenic sites may help characterize genetic polymorphisms that predispose to the formation of the antibody binding sites. Identification of antibody binding sites will enhance our understanding of the pathogenesis of immune drug-induced thrombocytopenia.

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Citations

Feb 10, 2004·Psychological Reports·James Robert Brasić
Aug 17, 2010·Indian Journal of Pharmacology·Surya KantRajendra Prasad
May 9, 2006·Critical Care Clinics·Erik R Vandendries, Reed E Drews
May 17, 2006·Platelets·Xiaojing LiuMervyn A Sahud
Sep 4, 2003·The Journal of Clinical Investigation·Mahtab MoayeriStephen H Leppla
Jan 11, 2007·Journal of Burn Care & Research : Official Publication of the American Burn Association·Bruce H AckermanLinwood R Haith
May 29, 2004·Transplantation·Andrew N de la TorreBaburao Koneru
Dec 14, 2004·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Patricia M L A van den BemtAntoine C G Egberts
Jul 2, 2020·BMJ Case Reports·Ghazal Kango, Faysal Haroun
Feb 7, 2009·Archives of Pathology & Laboratory Medicine·Barton Kenney, Gary Stack

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