Molecular mechanisms of ethanol-associated oro-esophageal squamous cell carcinoma

Cancer Letters
Yao LiuXiaoxin Chen

Abstract

Alcohol drinking is a major etiological factor of oro-esophageal squamous cell carcinoma (OESCC). Both local and systemic effects of ethanol may promote carcinogenesis, especially among chronic alcoholics. However, molecular mechanisms of ethanol-associated OESCC are still not well understood. In this review, we summarize current understandings and propose three mechanisms of ethanol-associated OESCC: (1) Disturbance of systemic metabolism of nutrients: during ethanol metabolism in the liver, systemic metabolism of retinoids, zinc, iron and methyl groups is altered. These nutrients are known to be associated with the development of OESCC. (2) Disturbance of redox metabolism in squamous epithelial cells: when ethanol is metabolized in oro-esophageal squamous epithelial cells, reactive oxygen species are generated and produce oxidative damage. Meanwhile, ethanol may also disturb fatty-acid metabolism in these cells. (3) Disturbance of signaling pathways in squamous epithelial cells: due to its physico-chemical properties, ethanol changes cell membrane fluidity and shape, and may thus impact multiple signaling pathways. Advanced molecular techniques in genomics, epigenomics, metabolomics and microbiomics will help us elucidate how...Continue Reading

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Citations

Sep 29, 2015·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Chien-Yang YehJiiang-Huei Jeng
Apr 1, 2017·Current Oncology Reports·Takashi Kojima, Toshihiko Doi
Oct 22, 2017·The Journal of Pathology·Zhaohui XiongXiaoxin Chen
Jan 15, 2019·Nutrition and Cancer·Geoffrey K Maiyoh, Vivian C Tuei
Dec 4, 2020·International Journal of Cancer. Journal International Du Cancer·Chung S Yang, Xiaoxin Luke Chen
Dec 15, 2020·The Journal of Pathology·Menghan ShiZhaohui Xiong

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