Molecular Mechanisms of Ferroptosis and Its Role in Pulmonary Disease

Oxidative Medicine and Cellular Longevity
Ningning TaoJingjing Liu

Abstract

Ferroptosis is a new mode of cell death that is characterized by the excessive accumulation of iron and lipid peroxides. It has unique morphological changes and disparate biochemical features and plays an intricate role in many pathophysiological processes. A great deal of researches confirms that ferroptosis can be regulated by numerous molecules through different mechanisms, supporting great potentials for novel pharmacological therapeutics. Recently, several studies reveal that ferroptosis is also closely associated with the initiation and development of respiratory disease. Understanding the specific mechanism, the molecular trait of ferroptosis and their relationship with pulmonary disease could provide significant references regarding effective treatment of these obstinate disease.

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Citations

Dec 10, 2020·Oxidative Medicine and Cellular Longevity·Xiang WeiDing-Sheng Jiang
Jun 12, 2021·Oxidative Medicine and Cellular Longevity·Sunao LiMingyang Zhang
Jul 13, 2021·Frontiers in Cell and Developmental Biology·Anran ZhangHuan Luo

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