Molecular mechanisms of general anesthesia.

Korean journal of anesthesiology
Yong Son

Abstract

General anesthetics produce a widespread neurodepression in the central nervous system by enhancing inhibitory neurotransmission and reducing excitatory neurotransmission. However, the action mechanisms of general anesthetics are not completely understood. Moreover, the general anesthetic state comprises multiple components (amnesia, unconsciousness, analgesia, and immobility), each of which is mediated by different receptors and neuronal pathways. Recently, neurotransmitter- and voltage-gated ion channels have emerged as the most likely molecular targets for general anesthetics. The gamma-aminobutyric acid type A (GABA(A)) receptors are leading candidates as a primary target of general anesthetics. This review summarizes current knowledge on how anesthetics modify GABA(A) receptor function.

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Citations

Sep 3, 2011·Journal of Neurochemistry·Christian P MüllerMaria A De Souza Silva
Jun 27, 2019·Journal of Neurophysiology·Fahad IqbalNaweed I Syed
Oct 23, 2018·World Journal of Methodology·Marco CascellaMaria Rosaria Muzio
Mar 20, 2021·Scientific Reports·Jordan SmithChristoph Simon

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