Molecular Mechanisms of Intercellular Dissemination of Bacterial Pathogens.

Trends in Microbiology
Georgina C DowdKeith Ireton

Abstract

Several intracellular bacterial pathogens, including Listeria monocytogenes, Shigella flexerni, and Rickettsia spp. use an actin-based motility process to spread in mammalian cell monolayers. Cell-to-cell spread is mediated by protrusive structures that contain bacteria encased in the host cell plasma membrane. These protrusions, which form in infected host cells, are internalized by neighboring cells. In this review, we summarize key findings on cell-to-cell spread, focusing on recent work on mechanisms of protrusion formation and internalization. We also discuss the dynamic behavior of bacterial populations during spread, and highlight recent findings showing that intercellular spread by an extracellular bacterial pathogen.

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Citations

Feb 13, 2021·International Journal of Molecular Sciences·Korinn N Murphy, Amanda J Brinkworth
Oct 6, 2021·Molecular Microbiology·Thilina U B HerathKeith Ireton
Oct 28, 2021·Molecular Microbiology·Keith IretonMazhar Hussain

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