Molecular mechanisms of lacrimal acinar secretory vesicle exocytosis

Experimental Eye Research
Kaijin WuSarah F Hamm-Alvarez

Abstract

The acinar epithelial cells of the lacrimal gland are responsible for the production, packaging and regulated exocytosis of tear proteins into ocular surface fluid. This review summarizes new findings on the mechanisms of exocytosis in these cells. Participating proteins are discussed within the context of different categories of trafficking effectors including targeting and specificity factors (rabs, SNAREs) and transport factors (microtubules, actin filaments and motor proteins). Recent information describing fundamental changes in basic exocytotic mechanisms in the NOD mouse, an animal model of Sjögren's syndrome, is presented.

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Citations

Jan 12, 2007·Molecular Biology of the Cell·Cheng-Chun WangWanjin Hong
Sep 22, 2006·Journal of Virology·Jiansong XieSarah F Hamm-Alvarez
Apr 25, 2008·American Journal of Physiology. Cell Physiology·Ronald R MarchellettaSarah F Hamm-Alvarez
Apr 29, 2011·American Journal of Physiology. Cell Physiology·Lilian ChiangSarah F Hamm-Alvarez
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