Molecular Mechanisms of lncRNAs in Regulating Cancer Cell Radiosensitivity

Bioscience Reports
Jiamin ZhuJing Cai

Abstract

Radiotherapy is one of the main modalities of cancer treatment. However, tumor recurrence following radiotherapy occurs in many cancer patients. A key to solving this problem is the optimization of radiosensitivity. In recent years, long non-coding RNAs (lncRNAs), which affect the occurrence and development of tumors through a variety of mechanisms, have become a popular research topic. LncRNAs have been found to influence radiosensitivity by regulating various mechanisms, including DNA damage repair, cell cycle arrest, apoptosis, cancer stem cells (CSCs) regulation, epithelial-mesenchymal transition (EMT), and autophagy. LncRNAs are expected to become a potential therapeutic target for radiotherapy in the future. This article reviews recent advances in the role and mechanism of lncRNAs in tumor radiosensitivity.

References

Jun 6, 2003·International Journal of Radiation Oncology, Biology, Physics·Anjali K GuptaW Gillies McKenna
Dec 2, 2008·PLoS Computational Biology·Marcel E DingerJohn S Mattick
Feb 4, 2009·Nature Reviews. Genetics·Tim R MercerJohn S Mattick
Feb 26, 2009·Cell·Chris P PontingWolf Reik
Nov 3, 2009·Neoplasia : an International Journal for Oncology Research·Laura SmithLynn Cawkwell
Jan 7, 2010·The Journal of Clinical Investigation·Natasha Y FrankMarkus H Frank
Apr 1, 2010·Journal of Mammary Gland Biology and Neoplasia·Chad J CreightonJeffrey M Rosen
Jul 23, 2011·Genes & Cancer·Maria-Magdalena Georgescu
Nov 29, 2011·Cancer Treatment Reviews·Chiara ForoniGiovanna Damia
Jul 31, 2012·Molecular Cell·Je-Hyun YoonMyriam Gorospe
Jul 9, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Rebecca BütofMichael Baumann
Jul 16, 2013·Clinical Oncology : a Journal of the Royal College of Radiologists·J S Good, K J Harrington
Dec 4, 2013·Leukemia & Lymphoma·Shadia ZamanVarsha Gandhi
Dec 7, 2013·Journal of the National Cancer Institute·David J Stewart
Nov 26, 2014·Annual Review of Medicine·Michael Goldstein, Michael B Kastan
Dec 31, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Li JingQiu Haifeng
Mar 1, 2015·Genomics, Proteomics & Bioinformatics·Jian ZhangShuangli Mi
May 8, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yan YangXinchen Sun
Aug 28, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hongzhi LuYing Su
Sep 24, 2015·Seminars in Cancer Biology·Ira SkvortsovaSergej Skvortsov
Oct 21, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yanhui JiangRufu Chen
Oct 21, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Chuan JinLei Ma
Dec 31, 2015·Oncotarget·Lei ChangYong Li
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yaoyong LuRongwei Liao
Apr 5, 2016·Nature Reviews. Genetics·Daniel W Thomson, Marcel E Dinger
Apr 26, 2016·Nature Structural & Molecular Biology·Youyou ZhangLin Zhang
Oct 8, 2016·Oncotarget·Qin-Nan ChenMing Sun
Oct 28, 2016·Advanced Drug Delivery Reviews·Sergio ReyBradly G Wouters
Oct 30, 2016·International Journal of Radiation Oncology, Biology, Physics·Rong ZhengYawei Yuan
Dec 10, 2016·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Zhijun LiJianmin Kong
Jan 15, 2017·Molecular Cancer Research : MCR·Yifan ChenJian-Ting Zhang

❮ Previous
Next ❯

Citations

Jun 17, 2020·Therapeutic Advances in Medical Oncology·Yidi QuDi Wang
Sep 13, 2020·Non-coding RNA·Lavinia RaimondiNicola Amodio
Feb 13, 2021·International Journal of Molecular Sciences·Hongxia LiuChunlin Shao
Jul 3, 2021·International Journal of Molecular Sciences·Yeonsoo ChaeWanyeon Kim
Nov 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiaoguang ZhouXiaodong Zhang

❮ Previous
Next ❯

Methods Mentioned

BETA
xenograft

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Autophagy & Metabolism

Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.

Autophagy & Disease

Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.

Parkinson's Disease & Autophagy (MDS)

Autophagy leads to degradation of damaged proteins and organelles by the lysosome. Impaired autophagy has been implicated in several diseases. Here is the role of autophagy in Parkinson’s disease.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis