Abstract
Long noncoding RNAs (lncRNAs) are non-protein coding transcripts longer than 200 nucleotides. Aberrant expression of lncRNAs has been found associated with gastric cancer, one of the most malignant tumors. By complementary base pairing with mRNAs or forming complexes with RNA binding proteins (RBPs), some lncRNAs including GHET1, MALAT1, and TINCR may mediate mRNA stability and splicing. Other lncRNAs, such as BC032469, GAPLINC, and HOTAIR, participate in the competing endogenous RNA (ceRNA) network. Under certain circumstances, ANRIL, GACAT3, H19, MEG3, and TUSC7 exhibit their biological roles by associating with microRNAs (miRNAs). By recruiting histone-modifying complexes, ANRIL, FENDRR, H19, HOTAIR, MALAT1, and PVT1 may inhibit the transcription of target genes in cis or trans. Through these mechanisms, lncRNAs form RNA-dsDNA triplex. CCAT1, GAPLINC, GAS5, H19, MEG3, and TUSC7 play oncogenic or tumor suppressor roles by correlated with tumor suppressor P53 or onco-protein c-Myc, respectively. In conclusion, interaction with DNA, RNA and proteins is involved in lncRNAs' participation in gastric tumorigenesis and development.
References
Mar 8, 1991·Science·E M Blackwood, R N Eisenman
Dec 29, 1995·Gene·R A DubinH Ostrer
Jun 10, 1998·Oncogene·T DugimontJ J Curgy
Apr 16, 2003·Genes & Development·Paula C FernandezBruno Amati
Apr 7, 2004·Cell·Marcel Tijsterman, Ronald H A Plasterk
Feb 14, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Anya N A MilneG Johan A Offerhaus
Jan 24, 2007·Nature·Igor MartianovAlexandre Akoulitchev
May 22, 2007·Cellular and Molecular Life Sciences : CMLS·J HäslerK Strub
Jun 16, 2007·The Journal of Biological Chemistry·Yunli ZhouAnne Klibanski
Jul 3, 2007·Cell·John L RinnHoward Y Chang
Sep 11, 2007·Seminars in Cancer Biology·Vito PistoiaSoldano Ferrone
Mar 12, 2008·Molecular and Cellular Biology·Sima Kheradmand KiaC Peter Verrijzer
Dec 2, 2008·Cell·Jeremy E WiluszDavid L Spector
May 19, 2009·Journal of Molecular Biology·Laurie A HeinickePhilip C Bevilacqua
Jul 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ahmad M KhalilJohn L Rinn
Feb 4, 2010·Science Signaling·Tomoshige KinoGeorge P Chrousos
Apr 8, 2010·Cell·Markus HafnerThomas Tuschl
Jun 15, 2010·Molecular Cell·Kyoko L YapMing-Ming Zhou
Jul 9, 2010·Cancer Cell·Haihe WangQi Zeng
Jul 10, 2010·Science·Miao-Chih TsaiHoward Y Chang
Aug 3, 2010·Cell·Maite HuarteJohn L Rinn
Aug 28, 2010·Molecular Cell·Vidisha TripathiKannanganattu V Prasanth
Jan 21, 2011·Nature·Raphaël Margueron, Danny Reinberg
Feb 11, 2011·Nature·Chenguang Gong, Lynne E Maquat
Apr 20, 2011·International Journal of Oncology·Chuan XuZuguo Li
May 6, 2011·Cell Death & Disease·Y ZhangR Ge
Oct 4, 2011·Molecular Cell·Ci ChuHoward Y Chang
Dec 7, 2011·Proceedings of the National Academy of Sciences of the United States of America·Matthew D SimonRobert E Kingston
Jun 6, 2012·Annual Review of Biochemistry·John L Rinn, Howard Y Chang
Jul 11, 2012·The FEBS Journal·Feng YangGuoen Fang
Sep 19, 2012·FEBS Letters·Sung Ho JeonYong Sun Lee
Sep 21, 2012·Oncology Reports·Mu-Han LüShi-Ming Yang
Sep 22, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Peng Qi, Xiang Du
Nov 13, 2012·Journal of Cancer Research and Clinical Oncology·Feng YangGuoen Fang
Dec 4, 2012·Nature·Markus KretzPaul A Khavari
Dec 12, 2012·Carcinogenesis·Ling ZhangShu-han Sun
Jan 29, 2013·Cancer Letters·Ming LuoJianxin Qiu
Feb 2, 2013·Developmental Cell·Phillip GroteBernhard G Herrmann
Apr 20, 2013·Experimental Biology and Medicine·Karin WilliamsSusan Kasper
May 7, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Weiliang SunJunming Guo
May 21, 2013·Gastroenterology·Zhengdeng LeiSteven G Rozen
Jul 23, 2013·Oncogene·H-P KimT-Y Kim
Sep 3, 2013·Medical Oncology·Danyi MeiJunming Guo
Sep 6, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ming SunXianghua Liu
Sep 17, 2013·RNA Biology·Phillip Grote, Bernhard G Herrmann
Sep 26, 2013·Journal of Translational Medicine·Haojun SongJunming Guo
Oct 17, 2013·PloS One·Hiroyuki EndoKennichi Satoh
Jan 9, 2014·The FEBS Journal·Feng YangGuoen Fang
Feb 1, 2014·Cell Death & Disease·L ChenS-M Yang
Feb 4, 2014·Genome Biology·Chammiran DanielMarie Öhman
Citations
Sep 21, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ling WangBao-En Shan
Sep 28, 2016·PloS One·Weijie MinZhijian Yue
Mar 13, 2017·Journal of Cancer Research and Clinical Oncology·Lei PanXu Zhang
Dec 3, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jin YanGuoxin Zhang
May 18, 2017·Nature Reviews. Gastroenterology & Hepatology·Nisha PadmanabhanPatrick Tan
Apr 1, 2018·Cancer·Xu YangLing Xu
Nov 16, 2017·Nucleic Acids Research·ShuangSang FangYi Zhao
Sep 17, 2016·Nucleic Acids Research·Marie KalwaWolfgang Wagner
Nov 4, 2017·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Tianwen LiJunming Guo
May 4, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yun LuXin-Hua Shi
Jun 24, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Heng DengJun Zhang
Dec 2, 2017·Journal of Cellular and Molecular Medicine·Yetao XuLizhou Sun
Apr 7, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jin-Xuan ZhaoYi-Mei Fan
Apr 27, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yongfu ShaoJunming Guo
Dec 15, 2017·Cell Death & Disease·Honglin YanJiacai Ren
Dec 15, 2017·Biomarkers in Medicine·Yi XieJunming Guo
Oct 25, 2017·Cancer Biomarkers : Section a of Disease Markers·Xiaoqin ZhuJunming Guo
Sep 25, 2017·Journal of Clinical Laboratory Analysis·Qianfu ZhaoXinjun Zhang
May 18, 2017·Future Oncology·Su-Rui ShengXin-Hua Liang
Jul 10, 2018·Oncogene·Fanyang KongKeping Xie
May 3, 2018·Bioscience Reports·Yeqian ZhangJia Xu
Aug 5, 2017·PloS One·Yingyi ZhangYao Li
Feb 12, 2019·Journal of Cellular Physiology·Zhao-Ling ChenXu Jing
Apr 3, 2019·Journal of Cellular Physiology·Shuwei Chen, Xinhu Xia
Apr 16, 2019·Journal of Cellular Physiology·Di CheXiaoqiong Gu
Jul 23, 2019·Journal of Clinical Laboratory Analysis·Rongdan LuJunming Guo
Jan 28, 2017·Cancer Biomarkers : Section a of Disease Markers·Weiliang SunJunming Guo
Oct 9, 2019·Journal of Cellular Physiology·Sadegh FattahiHaleh Akhavan-Niaki
Jan 21, 2020·Circulation. Heart Failure·Junyi YuGengze Wu
Feb 14, 2020·Cancer Medicine·Fen-Rong ChenJun Zhang
Dec 13, 2019·Cell Proliferation·Zheng LiWilliam K K Wu
Nov 9, 2019·Journal of Clinical Pharmacy and Therapeutics·Li ChenDazhuo Shi
Mar 7, 2020·Bioscience Reports·Xu-E ChenLiang Sheng
Dec 14, 2018·Oncotarget·Sijie ChengPenghui Yang
May 3, 2018·Oncotarget·Kanagaraj ArunArasambattu Kannan Munirajan
May 29, 2018·Oncotarget·Zhihui ZhangXinjian Yang
Apr 22, 2017·Oncotarget·Xiaomin LiuZhongliang Ma
Apr 15, 2017·Oncotarget·Liyun FuJunming Guo
Nov 9, 2017·Oncotarget·Jie LiuYing Song
Nov 22, 2017·Oncotarget·Wenyan HanXiulan Su
Oct 27, 2017·Oncotarget·Yuqing HeWeiming He
Nov 2, 2017·Oncotarget·Yunhong ZengDongsheng Hu
Jan 20, 2018·Oncotarget·Yajun LuoJiangwei Xiao
Sep 25, 2017·Oncotarget·Liyun FuJunming Guo
Oct 4, 2017·Oncotarget·Liying ZhuHua Tang
Jan 20, 2018·Oncotarget·Shikai ZhuYu Zhou
Oct 6, 2017·Oncotarget·Wen-Jie ChenGang Chen
Nov 9, 2017·Oncotarget·Ning-Bo HaoRui-Ling Wang
Dec 13, 2017·Oncotarget·Zhenghua LinShujie Chen
Oct 23, 2016·Oncotarget·Yongfu ShaoJunming Guo