Molecular mechanisms of MLL-associated leukemia

International Journal of Hematology
Akihiko Yokoyama

Abstract

Gene rearrangements of the mixed lineage leukemia (MLL) gene cause aggressive leukemia. The fusion of MLL and its partner genes generates various MLL fusion genes, and their gene products trigger aberrant self-renewal of hematopoietic progenitors leading to leukemia. Since the identification of the MLL gene two decades ago, a substantial amount of information has been obtained regarding the mechanisms by which MLL mutations cause leukemia. Wild-type MLL maintains the expression of Homeobox (HOX) genes during development. MLL activates the expression of posterior HOX-A genes in the hematopoietic lineage to stimulate the expansion of immature progenitors. MLL fusion proteins constitutively activate the HOX genes, causing aberrant self-renewal. The modes of transcriptional activation vary depending on the fusion partners and can be categorized into at least four groups. Here I review the recent progress in research related to the molecular mechanisms of MLL fusion-dependent leukemogenesis.

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Citations

Mar 11, 2015·International Journal of Hematology·Tomohiko Tamura
Sep 10, 2015·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·James R DavieGenevieve P Delcuve
Jun 14, 2016·Trends in Pharmacological Sciences·Katerina CermakovaZeger Debyser
Nov 21, 2016·Experimental Hematology·Akihiko Yokoyama
Jan 19, 2017·Cancer Science·Susumu Goyama, Toshio Kitamura
May 26, 2017·BMC Cancer·Estelle MenuJean Gabert
Aug 11, 2015·Oncotarget·Jennifer ChaseIvan Maillard
Jul 3, 2017·International Journal of Hematology·Suguru UemuraYoshiyuki Kosaka
Oct 28, 2019·Nature Communications·Yasutaka HayashiToshio Kitamura
Nov 6, 2020·Pediatric Hematology and Oncology·Shota KatoMitsuteru Hiwatari
Jan 15, 2017·The American Journal of Pathology·Laurent EhrlichShannon Glaser
Nov 6, 2021·Biomarker Research·A Torres-Montaner

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