Molecular Mechanisms of Neurogenic Aging in the Adult Mouse Subventricular Zone

Journal of Experimental Neuroscience
Giuseppe LupoEmanuele Cacci

Abstract

In the adult rodent brain, the continuous production of new neurons by neural stem/progenitor cells (NSPCs) residing in specialized neurogenic niches and their subsequent integration into pre-existing cerebral circuitries supports odour discrimination, spatial learning, and contextual memory capabilities. Aging is recognized as the most potent negative regulator of adult neurogenesis. The neurogenic process markedly declines in the aged brain, due to the reduction of the NSPC pool and the functional impairment of the remaining NSPCs. This decline has been linked to the progressive cognitive deficits of elderly individuals and it may also be involved in the onset/progression of neurological disorders. Since the human lifespan has been dramatically extended, the incidence of age-associated neuropsychiatric conditions in the human population has increased. This has prompted efforts to shed light on the mechanisms underpinning the age-related decline of adult neurogenesis, whose knowledge may foster therapeutic approaches to prevent or delay cognitive alterations in elderly patients. In this review, we summarize recent progress in elucidating the molecular causes of neurogenic aging in the most abundant NSPC niche of the adult mous...Continue Reading

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Citations

Jun 5, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Giuseppe LupoRodolfo Negri
Apr 5, 2020·Neural Regeneration Research·Giancarlo PoianaEmanuele Cacci
Jul 25, 2019·International Journal of Molecular Sciences·Luc Rochette, Gabriel Malka
Sep 5, 2019·International Journal of Molecular Sciences·Amanda Lo VanNathalie Bernoud-Hubac
Feb 8, 2020·Cells·Alessandro ZambusiJovica Ninkovic
Feb 10, 2021·International Journal of Molecular Sciences·Pietro Cacialli
Apr 17, 2021·Free Radical Biology & Medicine·Inah HwangJihye Paik

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Methods Mentioned

BETA
activated cell sorting

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