Molecular mechanisms of oestrogen and SERMs in endometrial carcinogenesis

Nature Reviews. Cancer
Yongfeng Shang

Abstract

Endometrial cancer is the most common gynaecological cancer, and is associated with endometrial hyperplasia, unopposed oestrogen exposure and adjuvant therapy for breast cancer using selective oestrogen-receptor modulators (SERMs), particularly tamoxifen. Oestrogen and SERMs are thought to be involved in endometrial carcinogenesis through their effects on transcriptional regulation. Ultimately, oestrogen and SERMs affect the transduction of cellular signalling pathways that govern cell growth and proliferation, through downstream effectors such as PAX2 (paired box 2).

References

Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·G R Dressler, E C Douglass
Oct 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·C M Szego, J S Davis
Aug 28, 1980·The New England Journal of Medicine·S ShapiroR C Knapp
Jun 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·B S KatzenellenbogenN Fujimoto
Dec 15, 1995·Cell·D J MangelsdorfR M Evans
Jan 1, 1995·Human Molecular Genetics·E T Stuart, P Gruss
May 17, 1996·Cell·M T Rogan, J E LeDoux
Sep 17, 1996·Proceedings of the National Academy of Sciences of the United States of America·E M McInerneyB S Katzenellenbogen
Dec 1, 1996·Human Pathology·U M MollJ Chumas
Jan 1, 1997·Human Molecular Genetics·M G DunlopB Vogelstein
Oct 24, 1997·Nature·A M BrzozowskiM Carlquist
Jan 7, 1998·Molecular and Cellular Biology·T WatanabeM Muramatsu
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·D M TanenbaumP B Sigler
Oct 17, 1998·Molecular Endocrinology·P WebbP J Kushner
Jan 12, 1999·The Journal of Steroid Biochemistry and Molecular Biology·J A RobertsonN H Ing
Jan 14, 1999·Oncology·D NiederacherM W Beckmann
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·L A PaigeD M Fowlkes
Feb 7, 2001·Trends in Endocrinology and Metabolism : TEM·D P McDonnell
Nov 5, 1999·The Journal of Biological Chemistry·P S JonesI N White
Mar 23, 2000·International Journal of Cancer. Journal International Du Cancer·Y R ParcA C Halling
Apr 29, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·S KounelisM W Jones
May 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·Z WeihuaJ A Gustafsson
Jun 8, 2000·Journal of the National Cancer Institute·G L MutterC Eng
Jul 19, 2000·Journal of Neurocytology·M R HutsonK F Barald

❮ Previous
Next ❯

Citations

Oct 28, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Martin Götte
Jan 26, 2012·Archives of Gynecology and Obstetrics·Korhan KahramanFırat Ortac
Feb 19, 2009·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Qinglei GaoDing Ma
Sep 19, 2006·Chemical Research in Toxicology·Tamara S DowersJudy L Bolton
Apr 12, 2007·Cell Research·Yongfeng Shang
May 27, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Julia TurbinerJosé Palacios
May 29, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Guo-Xia TongAlain C Borczuk
Jun 8, 2011·Nature Medicine·Christoforos Thomas, Jan-Ake Gustafsson
Jul 23, 2011·Nature Reviews. Cancer·Christoforos Thomas, Jan-Åke Gustafsson
Apr 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Lei ShiYongfeng Shang
Jul 9, 2010·The Journal of Biological Chemistry·Yu ZhangYongfeng Shang
Jan 14, 2009·The Journal of Experimental Medicine·Siim PauklinSvend K Petersen-Mahrt
Jun 10, 2009·Mutagenesis·Karen Brown
Nov 7, 2006·Nucleic Acids Research·Jorge Lopez-GarciaSimak Ali
Dec 25, 2008·Current Opinion in Oncology·Angelo Delmonte, Cristiana Sessa
Dec 18, 2010·The American Journal of Surgical Pathology·Wenxin ZhengBeihua Kong
Sep 4, 2010·Obstetrics and Gynecology International·Oscar Gee-Wan WongAnnie Nga-Yin Cheung
May 17, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Tapan K NayakEric R Prossnitz
Oct 10, 2012·Annual Review of Physiology·Jing Liang, Yongfeng Shang
Dec 8, 2007·Breast Cancer Research and Treatment·Wilhelmina E HoogendoornUNKNOWN Comprehensive Cancer Centers TAMARISK-group
Feb 9, 2012·Journal of Amino Acids·Raj KumarRavi Jasuja
Apr 1, 2009·Cellular and Molecular Life Sciences : CMLS·Stephan EllmannPamela L Strissel
Sep 17, 2009·Journal of Cancer Research and Clinical Oncology·Masashi TakanoMieko Shiwa
Jan 25, 2012·Journal of Cancer Research and Clinical Oncology·Yin-Yan HeXiao-Ping Wan
Feb 14, 2015·Expert Opinion on Therapeutic Targets·Xi-Wei JiWilliam C Cho
Nov 21, 2007·Expert Opinion on Therapeutic Targets·Atsushi TanemuraDave S B Hoon
Jun 12, 2009·Drug Metabolism Reviews·Shu-Feng ZhouBalram Chowbay
Jan 19, 2016·Molecular and Cellular Endocrinology·Yanchun Liang, Shuzhong Yao
Aug 31, 2011·Molecular and Cellular Endocrinology·Kaisa HuhtinenMatti Poutanen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.