PMID: 45003Oct 18, 1979

Molecular mechanisms of olfactory reception. IV. Some biochemical characteristics of the camphor receptor from rat olfactory epithelium

Biochimica Et Biophysica Acta
E E FesenkoL D Krapivinskaya


Some parameters of the receptor element from the rat olfactory epithelium are evaluated; it is characterized by high affinity for camphor (KD = 1.5. x 10(-9) M). Triton X-100 has no marked effect on the binding of [3H]camphor. Neither RNAase nor phospholipase C affected [3H]camphor-binding activity. Pronase and trypsin abolished [3H]camphor binding activity by 65 and 40%, respectively. Sulfhydryl reagents decrease the binding of [3H]camphor by a factor of 5--8. The isoelectric point of the receptor solubilized with Triton X-100 is 4.8, as determined by isoelectric focusing. The molecular weight of the receptor as determined by gel electrophoresis is about 120 000. It is proposed that the camphor receptor is a membrane protein containing sulfhydryl groups and playing a key role in olfactory reception.


Jan 1, 1984·Progress in Neurobiology·T V GetchellM L Getchell
Jan 1, 1986·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·N E BaldacciniA Topazzini
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J PevsnerS H Snyder
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J PevsnerS H Snyder
Jan 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M R LernerA Roby
Mar 15, 1986·Experientia·G Ohloff
Sep 26, 2007·The FEBS Journal·G B PostnikovaV S Sivozhelezov
Jan 1, 1988·Bioelectromagnetics·T M PhilippovaS I Alekseev
Jan 1, 1994·Critical Reviews in Biochemistry and Molecular Biology·P Pelosi
Jun 3, 1985·European Journal of Biochemistry·E BignettiR Tirindelli


Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·M L Getchell, R C Gesteland

Related Concepts

Smell Perception
Sulfhydryl Compounds
Plasma Protein Binding Capacity
Olfactory Mucosa
Sulfhydryl Reagents

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.