Molecular Mechanisms of Phosphodiesterase-5 Inhibitors on Neuronal Apoptosis

DNA and Cell Biology
Eduardo Duarte-Silva, Christina Alves Peixoto

Abstract

Phosphodiesterase-5 inhibitors (PDE5Is) have been shown to modulate cell death/cell survival in different in vivo and in vitro models of disease by activating many signaling pathways. This review aimed at elucidating how PDE5Is can inhibit apoptosis. In this study, we describe many signaling pathways involved with the mechanism of action of PDE5Is that ultimately inhibit apoptosis and thus promote cell survival.

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Citations

May 22, 2019·Frontiers in Endocrinology·Antonio AversaSandro La Vignera
Feb 15, 2020·Journal of Affective Disorders·Eduardo Duarte-SilvaChristina Peixoto
Jun 6, 2020·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Zhidong XuQi-Huang Zheng

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis