PMID: 6105885Aug 7, 1980Paper

Molecular mechanisms of photoreception. IV. Ca2+-inhibited GTPase of rod outer segments of the frog retina

Biochimica Et Biophysica Acta
G B KrapivinskyE E Fesenko

Abstract

Ca2+-dependent GTPase activity is found to be present in the rod outer segments of frog retina. GTPase localization in rod outer segments is shown by fractionating the rod outer segment preparation in the sucrose density gradient. The enzyme is readily washed out of cells with isotonic NaCl solution. The Km is 0.6 mM for GTP. The activity is inhibited by 78 +/- 12% with the increase in Ca2+ concentration from 10(-9) to 10(-7) M. GTP hydrolysis is inhibited by the same concentrations of Ca2+ which block the sodium conductivity of the rod outer segment cytoplasmic membrane.

References

Oct 1, 1977·Nature·G L WheelerM W Bitensky
Oct 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·G L Wheeler, M W Bitensky
Jun 1, 1978·The Journal of Physiology·E BignettiR T Sorbi
Nov 14, 1978·Biochemical and Biophysical Research Communications·F A de AzeredoJ V Passonneau
Jun 1, 1976·The Journal of Physiology·A Carretta, A Cavaggioni
Dec 1, 1976·Annals of Internal Medicine·E Gordis
Mar 1, 1974·Experimental Eye Research·W A Hagins, S Yoshikami
Aug 1, 1972·Biophysical Journal·R D Penn, W A Hagins

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Citations

Jun 1, 1982·Photochemistry and Photobiology·A Maeda, T Yoshizawa

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