Molecular Mechanisms of Polybrominated Diphenyl Ethers (BDE-47, BDE-100, and BDE-153) in Human Breast Cancer Cells and Patient-Derived Xenografts.

Toxicological Sciences : an Official Journal of the Society of Toxicology
Noriko KanayaShiuan Chen

Abstract

Polybrominated diphenyl ethers (PBDEs) have been used as flame retardants in household materials. Their environmental persistence has led to continuous human exposure and significant tissue levels. Three PBDE congeners (BDE-47, BDE-100, and BDE-153) have been frequently detected in human serum. Although these compounds appear to possess endocrine disrupting activity, studies are largely missing to determine the biological mechanisms of PBDEs in breast cancer cells. Here, we assessed PBDE bioactivities with three complementary strategies: receptor binding/activity assays; nonbiased RNA-sequencing analysis using an estrogen-dependent breast cancer cell line MCF-7aroERE; and in vivo assessments using patient-derived xenograft (PDX) models of human breast cancer. According to the results from in vitro experiments, the PBDE congeners regulate distinct nuclear receptor signaling pathways. BDE-47 acts as a weak agonist of both estrogen receptor α (ERα) and estrogen-related receptor α (ERRα); it could stimulate proliferation of MCF-7aroERE and induced expression of ER-regulated genes (including cell cycle genes). BDE-153 was found to act as a weak antagonist of ERα. BDE-100 could act as (1) an agonist of aryl hydrocarbon receptor (AhR)...Continue Reading

References

Feb 28, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·Tong ZhouKevin M Crofton
Jul 5, 2003·Environmental Health Perspectives·Myrto PetreasM Judith Charles
Sep 30, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Guosheng Chen, Nigel J Bunce
Mar 5, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·Tammy E StokerRalph L Cooper
Oct 29, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·D F StaskalL S Birnbaum
Aug 9, 2005·Environmental Science & Technology·Boris Johnson-RestrepoBruce D Rodan
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aravind SubramanianJill P Mesirov
Feb 28, 2006·Bioinformatics·Fan HsuDavid Haussler
Apr 8, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Timo HamersAbraham Brouwer
Apr 28, 2006·Nature Genetics·Michael ReichJill P Mesirov
Mar 8, 2007·The Journal of Clinical Endocrinology and Metabolism·Ayse Gonca ImirSerdar E Bulun
Oct 6, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jing ShaoEvan P Gallagher
Feb 6, 2008·Toxicology Letters·Yuhe HePaul K S Lam
Jun 3, 2008·Nature Methods·Ali MortazaviBarbara Wold
May 27, 2009·American Journal of Epidemiology·Ross L PrenticeJacques E Rossouw
Oct 20, 2012·American Journal of Public Health·Gillian HaberVukosava Pekovic
Aug 21, 2013·PLoS Computational Biology·Michael LawrenceVincent J Carey
Dec 7, 2013·Cancer & Metabolism·Shawn McGuirkJulie St-Pierre
Feb 6, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Shiuan ChenChristina Teng
Sep 28, 2014·Bioinformatics·Simon AndersWolfgang Huber
Dec 17, 2014·Acta Pharmacologica Sinica·Étienne Audet-Walsh, Vincent Giguére
Jul 5, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Shiuan ChenRaymond R Tice
Nov 13, 2015·Seminars in Immunology·Marina Cella, Marco Colonna
Dec 24, 2015·Chemosphere·Weihong GuoJune-Soo Park
Apr 14, 2016·CNS & Neurological Disorders Drug Targets·Sarah Wong, Cecilia Giulivi
May 8, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Noriko KanayaShiuan Chen

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Citations

Mar 7, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Gregory ChangShiuan Chen
Apr 6, 2021·Critical Reviews in Food Science and Nutrition·Murphy Lam Yim WanHani El-Nezami
Aug 28, 2021·International Journal of Molecular Sciences·Xiaoqiang WangShiuan Chen

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