Molecular Mechanisms of Renal Ischemic Conditioning Strategies

European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
Casper Kierulf-LassenFrank J M F Dor

Abstract

Ischemia-reperfusion injury is the leading cause of acute kidney injury in a variety of clinical settings such as renal transplantation and hypovolemic and/or septic shock. Strategies to reduce ischemia-reperfusion injury are obviously clinically relevant. Ischemic conditioning is an inherent part of the renal defense mechanism against ischemia and can be triggered by short periods of intermittent ischemia and reperfusion. Understanding the signaling transduction pathways of renal ischemic conditioning can promote further clinical translation and pharmacological advancements in this era. This review summarizes research on the molecular mechanisms underlying both local and remote ischemic pre-, per- and postconditioning of the kidney. The different types of conditioning strategies in the kidney recruit similar powerful pro-survival mechanisms. Likewise, renal ischemic conditioning mobilizes many of the same protective signaling pathways as in other organs, but differences are recognized.

Citations

Dec 15, 2015·The British Journal of Surgery·A I SutherlandF J M F Dor
Jul 14, 2016·Physiological Reports·Marie Louise V KristensenRikke Nørregaard
Jul 28, 2017·Journal of the American Society of Nephrology : JASN·Jesus H DominguezK J Kelly
Oct 4, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·N V KrogstrupB Jespersen
Mar 28, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Qin YangXiao-Ming Meng
Sep 28, 2021·American Journal of Physiology. Renal Physiology·Zhi-Lin LuanXiao-Yan Zhang

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