Molecular mechanisms of RET receptor-mediated oncogenesis in multiple endocrine neoplasia 2.

Clinics
Simona M WagnerLois M Mulligan

Abstract

Multiple endocrine neoplasia type 2 is an inherited cancer syndrome characterized by tumors of thyroid and adrenal tissues. Germline mutations of the REarranged during Transfection (RET) proto-oncogene, leading to its unregulated activation, are the underlying cause of this disease. Multiple endocrine neoplasia type 2 has been a model in clinical cancer genetics, demonstrating how knowledge of the genetic basis can shape the diagnosis and treatment of the disease. Here, we discuss the nature and effects of the most common recurrent mutations of RET found in multiple endocrine neoplasia type 2. Current understanding of the molecular mechanisms of RET mutations and how they alter the structure and function of the RET protein leading to its aberrant activation, and the effects on RET localization and signaling are described.

Citations

Jul 1, 2015·Molecular and Cellular Endocrinology·Charlotte Lepoutre-LusseyJudith Favier
Aug 8, 2015·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Antonella VerrientiRocco Bruno
Jul 12, 2016·Pediatric Dermatology·Francisco AlcántaraRaúl De Lucas
Feb 11, 2018·Cell and Tissue Research·Charlotte Lussey-LepoutreJudith Favier
Oct 31, 2012·International Journal of Molecular Sciences·Ke MaZheng Li

❮ Previous
Next ❯

Methods Mentioned

BETA
protein folding
prophylactic surgery

Related Concepts

Related Feeds

Autoimmune Polyendocrine Syndromes

This feed focuses on a rare genetic condition called Autoimmune Polyendocrine Syndromes, which are characterized by autoantibodies against multiple endocrine organs. This can lead to Type I Diabetes.