Molecular mechanisms of the action of Arctigenin in cancer

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Yinghua HeZheng Shi

Abstract

Since antediluvian times, the scientific community has realized that natural compounds exhibit enormous potential for the treatment of terrible diseases, such as cancer. Despite a variety of effective bioactive molecules, effective therapies still need to be developed to treat cancer. Hence, it is necessary to study the interactions of natural molecules with their cellular targets. Arctigenin (ATG), a natural lignan compound extracted from Arctium lappa, inhibits the growth of various cancer cells, such as those of the stomach, lungs, liver, and colon, as well as leukocytes, and regulates numerous intracellular activities, such as antioxidative, anti-inflammatory, and anticancer activities. The intention of this paper is to summarize and generally analyse the molecular pathways that are involved in the anticancer effects of ATG. In addition, the interactions of ATG with other drugs are also highlighted in this paper.

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Citations

Mar 25, 2020·Journal of Natural Medicines·Shinya OkuboTakuhiro Uto
Jul 29, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xavier MontanéBartosz Tylkowski
Aug 1, 2019·Medicines·Bruno A C NascimentoKarina F Zoccal
Sep 6, 2020·International Journal of Molecular Sciences·Hui ShiHuabao Xiong
Oct 6, 2020·BioMed Research International·Yong'an JiangRu'en Liu
Sep 27, 2019·Pharmacological Reviews·Dongdong WangAtanas G Atanasov
Dec 6, 2019·Journal of Ethnopharmacology·Dongdong WangVerena M Dirsch
Feb 27, 2021·Molecular and Cellular Biochemistry·Violetta Krajka-KuźniakWanda Baer-Dubowska
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nour El KhatibNathalie Saint
Aug 29, 2020·Endocrine Regulations·Dariia O TsymbalOleksandr H Minchenko
Jul 21, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·Sutthiwan JanthamalaAnchalee Techasen
Oct 14, 2021·Organic & Biomolecular Chemistry·Lisa-Maria RečnikChristine L Willis

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