PMID: 9638516Jan 1, 1997Paper

Molecular mechanisms of the exaggerated growth of vascular smooth muscle cells in hypertension

Journal of Atherosclerosis and Thrombosis
N Fukuda

Abstract

The molecular mechanisms of the exaggerated growth of vascular smooth muscle cells (VSMC) in hypertension are reviewed based on our previous experimental data. Spontaneously hypertensive rats (SHR)-derived VSMC increasingly express angiotensinogen, cathepsin D and angiotensin-converting enzyme (ACE) mRNAs, compared to cells from normotensive Wistar-Kyoto (WKY) rats, indicating the presence of an Ang II generating system in a homogeneous culture of VSMC from SHR. The produced Ang II then induces TGF-beta. SHR-derived VSMC show the distinct expression and abnormal regulation by Ang II of TGF-beta receptors when compared with cells from WKY rats, which express TGF-beta type II receptor predominantly to induce PDGF A-chain stimulation of VSMC growth. These findings imply that the increased growth of VSMC in hypertension is a primary event independent of high blood pressure, and is associated with endogenous Ang II-related growth factors.

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Citations

Jul 27, 2007·Clinical and Experimental Hypertension : CHE·Bo WangYing Wang
Apr 11, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E PerfilievaP S Eriksson
Apr 2, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yi-Mu LaiKatsuo Kanmatsuse
Dec 18, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yoshiko TahiraKatsuo Kanmatsuse
Jul 28, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Ernesto L Schiffrin, Rhian M Touyz
Jun 10, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·W Y HuK Kanmatsuse
Jul 29, 2003·Journal of Cardiovascular Pharmacology·Noboru FukudaKatsuo Kanmatsuse
Oct 21, 2000·American Journal of Hypertension·A KuboK Kanmatsuse

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