Molecular mechanisms of the formation and progression of intracranial aneurysms

Neurologia Medico-chirurgica
Hiroharu Kataoka

Abstract

Until recently, only a little was understood about molecular mechanisms of the development of an intracranial aneurysm (IA). Recent advancements over the last decade in the field of genetics and molecular biology have provided us a wide variety of evidences supporting the notion that chronic inflammation is closely associated with the pathogenesis of IA development. In the field of genetics, large-scale Genome-wide association studies (GWAS) has identified some IA susceptible loci and genes related to cell cycle and endothelial function. Researches in molecular biology using human samples and animal models have revealed the common pathway of the initiation, progression, and rupture of IAs. IA formation begins with endothelial dysfunction followed by pathological remodeling with degenerative changes of vascular walls. Medical treatments inhibiting inflammatory cascades in IA development are likely to prevent IA progression and rupture. Statins and aspirin are expected to suppress IA progression by their anti-inflammatory effects. Decoy oligodeoxynucleotides (ODNs) inhibiting inflammatory transcription factors such as nuclear factor kappa-B (NF-κB) and Ets-1 are the other promising choice of the prevention of IA development. Furt...Continue Reading

References

Mar 1, 1987·Neuropathology and Applied Neurobiology·F Hazama, N Hashimoto
Sep 1, 1986·Stroke; a Journal of Cerebral Circulation·M KojimaF Hazama
Sep 1, 1995·Journal of Neurosurgery·W I SchievinkD G Piepgras
Jan 1, 1993·Journal of Cardiovascular Pharmacology·R M NeremR W Alexander
Oct 1, 1994·Stroke; a Journal of Cerebral Circulation·W I SchievinkV V Michels
Apr 1, 1994·Stroke; a Journal of Cerebral Circulation·W I SchievinkD G Piepgras
Nov 1, 1993·Neurosurgery·A RonkainenM Ryynänen
Jan 1, 1995·Journal of Cardiovascular Pharmacology·P LibbyZ S Galis
Oct 6, 1997·Neurosurgery·S C KimE S Connolly
Jan 28, 1998·Stroke; a Journal of Cerebral Circulation·S KondoH Kataoka
Sep 2, 1998·Journal of Neurosurgery·G BrunoD Chyatte
Nov 7, 1998·The Journal of Biological Chemistry·I S BhullarS Chien
Nov 13, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·S BellostaF Bernini
May 1, 1999·Journal of Neurosurgery·K TakenakaN Sakai
Nov 5, 1999·Neurosurgery·D ChyatteD R Todor
Oct 25, 2000·Acta Neuropathologica·N NakajimaK Satoh
Jul 4, 2001·The Journal of Clinical Investigation·S L TilleyB H Koller
Aug 3, 2002·BMC Medical Genetics·Jane M OlsonGerard Tromp
Feb 11, 2003·Journal of Cellular Biochemistry·Herbert M Kagan, Wande Li
Mar 22, 2003·Stroke; a Journal of Cerebral Circulation·Shigeki YamadaAkio Koizumi
Apr 12, 2003·Stroke; a Journal of Cerebral Circulation·Anne HoferGeorg Auburger
Jun 7, 2003·Science·Gregory M Barton, Ruslan Medzhitov
Jul 18, 2003·Lancet·David O WiebersUNKNOWN International Study of Unruptured Intracranial Aneurysms Investigators
Nov 8, 2003·Human Genetics·James M FarnhamLisa A Cannon-Albright
Nov 15, 2003·Stroke; a Journal of Cerebral Circulation·Nobutake SadamasaNobuo Hashimoto
Jan 24, 2004·Stroke; a Journal of Cerebral Circulation·Taku YoneyamaIturo Inoue
Nov 13, 2004·American Journal of Human Genetics·Brian V NahedMurat Gunel
Feb 5, 2005·Pathophysiology of Haemostasis and Thrombosis·H Roger Lijnen
May 14, 2005·Stroke; a Journal of Cerebral Circulation·Nicole Berthelemy-OkazakiLisa A Cannon-Albright

❮ Previous
Next ❯

Citations

Aug 10, 2016·Frontiers in Surgery·Vernard S FennellRobert F Spetzler
Sep 19, 2016·The International Journal of Biochemistry & Cell Biology·Saverio Francesco Retta, Angela J Glading
Sep 6, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Christoph J GriessenauerClemens M Schirmer
Dec 27, 2018·JAMA Surgery·Mark R Goldstein, Luca Mascitelli
Mar 23, 2019·Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko·I F Gareev, Sh M Safin
Jun 22, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Crissey L PascaleAaron S Dumont
Aug 17, 2017·Arquivos de neuro-psiquiatria·Iracema Araújo EstevãoPaulo Henrique Pires de Aguiar
Dec 14, 2018·Medical & Biological Engineering & Computing·Khalid M SaqrMakoto Ohta
Jun 17, 2020·Neurologia Medico-chirurgica·Hiroharu KataokaSusumu Miyamoto
Mar 9, 2021·Journal of Drug Targeting·Zhixian JiangJinning Zhang
Apr 3, 2021·Journal of the Neurological Sciences·Jienan WangYueqi Zhu

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging technique
immunoprecipitation
acetylation

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Antisense Oligonucleotides: ND

This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.