Molecular mechanisms of the novel coronavirus SARS-CoV-2 and potential anti-COVID19 pharmacological targets since the outbreak of the pandemic

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Dimitrios VlachakisFlora Bacopoulou

Abstract

The novel coronavirus SARS-CoV-2 has emerged as a severe threat against public health and global economies. COVID-19, the disease caused by this virus, is highly contagious and has led to an ongoing pandemic. SARS-CoV-2 affects, mainly, the respiratory system, with most severe cases primarily showcasing acute respiratory distress syndrome. Currently, no targeted therapy exists, and since the number of infections and death toll keeps rising, it has become a necessity to study possible therapeutic targets. Antiviral drugs can target various stages of the viral infection, and in the case of SARS-CoV-2, both structural and non-structural proteins have been proposed as potential drug targets. This review focuses on the most researched SARS-CoV-2 proteins, their structure, function, and possible therapeutic approaches.

References

Aug 30, 2001·The Journal of Biological Chemistry·A A JohnsonK A Johnson
Feb 19, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Vicente FalcóAlbert Pahissa
May 19, 2004·Biochemistry·Qiulong HuangEdward T Olejniczak
Nov 20, 2004·Emerging Infectious Diseases·Xiao-Yan CheKwok-Yung Yuen
Feb 25, 2005·Antimicrobial Agents and Chemotherapy·Yousuke FurutaKimiyasu Shiraki
Jun 17, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Huub Schellekens
Oct 18, 2005·Journal of Biomedical Science·Chung-ke ChangTai-huang Huang
Apr 14, 2006·Current Pharmaceutical Design·Ching-Hsiu TsaiMei-Ling Li
Jan 19, 2007·Journal of Virology·Ye Ye, Brenda G Hogue
May 29, 2007·Cellular and Molecular Life Sciences : CMLS·D X LiuY Liao
Jul 25, 2007·Angewandte Chemie·Nan YangJian-Dong Huang
Aug 21, 2007·Journal of Medical Virology·Xiaonan FangLinbai Ye
Oct 25, 2007·Chemical Communications : Chem Comm·Nan YangHongzhe Sun
Oct 30, 2007·Trends in Immunology·Anne S De Groot, David W Scott
Feb 5, 2008·Biochemical and Biophysical Research Communications·Yingchun ZengZhenghui Wu
Feb 24, 2009·Bioorganic & Medicinal Chemistry Letters·Chaewoon LeeYouhoon Chong
Oct 24, 2009·Nature Reviews. Cancer·Hua YuRichard Jove
Feb 16, 2010·The Journal of Biological Chemistry·Ying-Tzu TsengChin-Tien Wang
Aug 20, 2010·Journal of Virology·Ariel L ArndtBrenda G Hogue
Dec 7, 2010·Journal of Structural Biology·Benjamin W NeumanMichael J Buchmeier
Apr 19, 2013·Scientific Reports·Darryl FalzaranoHeinz Feldmann
May 22, 2013·Biochimica Et Biophysica Acta·Carmina Verdiá-BáguenaVicente M Aguilella
Jan 15, 2014·Antiviral Research·Chung-ke ChangTai-huang Huang
Aug 12, 2014·Viruses·Ruth McBrideBurtram C Fielding
Oct 3, 2014·Molecular Pharmacology·Brooke M RockKent L Kunze

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Citations

Jan 16, 2021·Journal of Biomolecular Structure & Dynamics·Sapan ShahUsha Nayak
Feb 16, 2021·Network Modeling and Analysis in Health Informatics and Bioinformatics·Sapan ShahGovind Lohiya
Mar 9, 2021·Journal of Pharmaceutical Sciences·K Abraham PeeleT C Venkateswarulu
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mohammad Hassan BaigJae-June Dong
Jun 3, 2021·Journal of Xenobiotics·Khalid O AlfaroukStephan J Reshkin
Aug 8, 2021·Reviews in Medical Virology·Maryam Yousefi DehbidiMohammad Doroudian

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Methods Mentioned

BETA
RNA-seq
ubiquitination

Software Mentioned

PLpro

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Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.