PMID: 19928047Nov 26, 2009Paper

Molecular mechanisms of the polymerization of fibrin and the formation of its three-dimensional network

Bioorganicheskaia khimiia
E V LugovskoĭS V Komisarenko

Abstract

The results of biochemical, immunochemical, and X-ray studies of the structures of fibrinogen and fibrin molecules were analyzed. The mechanisms of the successive formation of the fibrin three-dimensional network were described: the polymerization of monomeric molecules with the formation of bifilar protofibrils, the lateral association of protofibrils, and the embranchment of the forming fibrils. Data on the electron and confocal microscopy of the polymeric fibrin were considered. The role of the known polymerization centers of fibrin which participated in the formation of protofibrils and their lateral association was discussed. Data on the existence of the previously unknown polymerization centers were given. In particular, the experimental results demonstrated that one of such centers which participated in the formation of protofibrils was located in the Bbeta12-46 fragment, and did not require the cleavage of fibrinopeptide B for its functioning. The results of the computer modeling of the spatial structure of the fibrin(ogen) molecule and the intermolecular interactions in the course of the fibrin polymerization were presented. The location of the alphaC domains in the fibrin(ogen) molecule and their role in the polymeriz...Continue Reading

References

Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A P Laudano, R F Doolittle
Jan 9, 1979·Biochemistry·K W WattR F Doolittle
Jan 1, 1978·Macromolecules·M E Carr, J Hermans
Sep 1, 1978·Thrombosis Research·H BoumaR F Doolittle
May 1, 1976·Thrombosis Research·B BlombäckD Hogg
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M W MosessonJ P DiOrio
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J W WeiselL Makowski
Jul 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·P A McKeeR L Hill
Feb 1, 1980·The Journal of Clinical Investigation·Y Sakata, N Aoki
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·R C Williams
Oct 13, 1981·Biochemistry·C Wolfenstein-Todel, M W Mosesson
Nov 8, 1994·Biochemistry·K A Moskowitz, A Z Budzynski
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y Fu, G Grieninger
Jun 7, 1994·Biochemistry·O V GorkunJ W Weisel
Mar 1, 1996·The Journal of Biological Chemistry·J L WoodheadJ W Weisel
Aug 9, 1996·The Journal of Biological Chemistry·J H Sobel, M A Gawinowicz
May 30, 1997·The Journal of Biological Chemistry·L A Falls, D H Farrell
Jul 1, 1997·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·M W Mosesson
Mar 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·Y VeklichJ W Weisel
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·G SpraggonG Grieninger
Nov 5, 1999·Biophysical Journal·E A RyanL Lorand

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Citations

Dec 19, 2012·Journal of Biomechanics·Gilead Moiseyev, Pinhas Z Bar-Yoseph
Jul 17, 2014·Biophysical Journal·Thomas H S van KempenFrans N van de Vosse
Nov 6, 2012·Journal of Biomechanics·Gilead MoiseyevPinhas Z Bar-Yoseph
Feb 26, 2015·PloS One·Igal BucayNathan E Hudson
Jun 21, 2017·BioMed Research International·Nathan E Hudson

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