PMID: 9429819Jan 16, 1998Paper

Molecular mechanisms of vascular smooth muscle cell growth

Current Opinion in Cardiology
S HafiziM H Yacoub

Abstract

In recent years, much progress has been made in elucidating the complex but orchestrated series of molecular events that drives a vascular smooth muscle cell to undergo proliferation. These events are initiated by mitogenic stimuli, such as platelet-derived growth factor binding to its receptor and triggering an intracellular signal transduction cascade, leading ultimately to cell-cycle progression and cell division. The signaling pathways that take place in response to both hyperplastic and hypertrophic agents, which include the mitogen-activated protein kinase and p70 S6 kinase, are discussed. In addition, novel protein kinase mediators, such as phosphatidylinositol 3-kinase and protein kinase B, and mechanisms that have recently been implicated in vascular smooth muscle cell growth are described.

Citations

Jan 5, 2002·The New England Journal of Medicine·Federico QuainiPiero Anversa
Aug 5, 2015·Advances in Biological Regulation·Adrien LupieriMuriel Laffargue
Aug 20, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Sassan HafiziChristopher G Proud

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