Molecular Mechanisms of White Spot Syndrome Virus Infection and Perspectives on Treatments

Viruses
Bas VerbruggenCharles R Tyler

Abstract

Since its emergence in the 1990s, White Spot Disease (WSD) has had major economic and societal impact in the crustacean aquaculture sector. Over the years shrimp farming alone has experienced billion dollar losses through WSD. The disease is caused by the White Spot Syndrome Virus (WSSV), a large dsDNA virus and the only member of the Nimaviridae family. Susceptibility to WSSV in a wide range of crustacean hosts makes it a major risk factor in the translocation of live animals and in commodity products. Currently there are no effective treatments for this disease. Understanding the molecular basis of disease processes has contributed significantly to the treatment of many human and animal pathogens, and with a similar aim considerable efforts have been directed towards understanding host-pathogen molecular interactions for WSD. Work on the molecular mechanisms of pathogenesis in aquatic crustaceans has been restricted by a lack of sequenced and annotated genomes for host species. Nevertheless, some of the key host-pathogen interactions have been established: between viral envelope proteins and host cell receptors at initiation of infection, involvement of various immune system pathways in response to WSSV, and the roles of vari...Continue Reading

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Citations

Feb 22, 2017·Journal of Invertebrate Pathology·Hansam ChoYoung Bong Kim
Jun 28, 2019·Diseases of Aquatic Organisms·Jaturon ThipwongAmornrat Phongdara
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Jun 18, 2021·Beilstein Journal of Organic Chemistry·Santiago Ramos-CarreñoRuben D Cadena-Nava

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Datasets Mentioned

BETA
AF440570

Methods Mentioned

BETA
genotyping
phage display
GTPases
GTPase
two-hybrid
ubiquitination
pulldown
Atomic Force Microscopy

Software Mentioned

TRANSFAC
JASPAR

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