Molecular mechanisms regulating macrophage response to hypoxia.

Frontiers in Immunology
Michal A RahatNitza Lahat

Abstract

Monocytes and Macrophages (Mo/Mɸ) exhibit great plasticity, as they can shift between different modes of activation and, driven by their immediate microenvironment, perform divergent functions. These include, among others, patrolling their surroundings and maintaining homeostasis (resident Mo/Mɸ), combating invading pathogens and tumor cells (classically activated or M1 Mo/Mɸ), orchestrating wound healing (alternatively activated or M2 Mo/Mɸ), and restoring homeostasis after an inflammatory response (resolution Mɸ). Hypoxia is an important factor in the Mɸ microenvironment, is prevalent in many physiological and pathological conditions, and is interdependent with the inflammatory response. Although Mo/Mɸ have been studied in hypoxia, the mechanisms by which hypoxia influences the different modes of their activation, and how it regulates the shift between them, remain unclear. Here we review the current knowledge about the molecular mechanisms that mediate this hypoxic regulation of Mɸ activation. Much is known about the hypoxic transcriptional regulatory network, which includes the master regulators hypoxia-induced factor-1 and NF-κB, as well as other transcription factors (e.g., AP-1, Erg-1), but we also highlight the role of ...Continue Reading

Citations

Jul 23, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Selma Giorgio
Mar 22, 2016·Mediators of Inflammation·Michal A Rahat, Jivan Shakya
Jun 27, 2013·Wiley Interdisciplinary Reviews. Developmental Biology·Ryan S UdanMary E Dickinson
Feb 18, 2015·Trends in Immunology·Christian Bogdan
Dec 3, 2014·Biochemical and Biophysical Research Communications·Akane SuekiTakayuki Honda
Nov 28, 2012·International Immunology·Elena RiboldiAntonio Sica
May 18, 2016·Anesthesiology·Harmke D KiersMatthijs Kox
Oct 5, 2020·Archivum Immunologiae Et Therapiae Experimentalis·Theodoros EleftheriadisIoannis Stefanidis
Apr 1, 2020·Journal of Cellular and Molecular Medicine·Kyung Don YooSeung Hee Yang
Jun 17, 2020·Journal of Experimental & Clinical Cancer Research : CR·Antonietta Rosella FarinaAndrew Reay Mackay
Jan 31, 2021·Vaccines·Joel MintzHimanshu Arora
Aug 17, 2020·Cellular Immunology·Hiba Yaseen, Mogher Khamaisi
Apr 11, 2021·Colloids and Surfaces. B, Biointerfaces·He ZhangRuiqiang Hang
Jun 17, 2021·Cell Reports·Laure-Anne TeuwenPeter Carmeliet

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Methods Mentioned

BETA
confocal microscopy
GTPases
ELISA

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