Molecular mechanisms related to the hepatoprotective effects of antioxidant-rich extra virgin olive oil supplementation in rats subjected to short-term iron administration

Free Radical Biology & Medicine
Cynthia BarreraLuis A Videla

Abstract

Enhanced iron levels in liver are associated with oxidative stress development and damage with increased fat accumulation. The aim of this work was to assess the hypothesis that antioxidant-rich extra virgin olive oil (AR-EVOO) counteracts iron-rich diet (IRD)-induced oxidative stress hindering hepatic steatosis. Male Wistar rats were fed and IRD (200 mg iron/kg diet) versus a control diet (CD; 50 mg iron/kg diet) with alternate AR-EVOO supplementation (100 mg/day) for 21 days. IRD induced liver steatosis and oxidative stress (higher levels of protein oxidation and lipid peroxidation with glutathione depletion), mitochondrial dysfunction (decreased citrate synthase and complex I and II activities) and loss of polyunsaturated fatty acids (PUFAs), with a drastic enhancement in the sterol regulatory element-binding protein-1c (SREBP-1c)/peroxisome proliferator-activated receptor-α (PPAR-α) ratio upregulating the expression of lipogenic enzymes (acetyl-CoA carboxylase, fatty acid (FA) synthase and stearoyl desaturase 2) and downregulating those involved in FA oxidation (carnitine palmitoyl transferase and acyl-CoA oxidase) over values in the CD group. IRD also upregulated nuclear factor erythroid 2-related factor 2 (Nrf2) and its t...Continue Reading

Citations

Jun 20, 2019·Expert Review of Gastroenterology & Hepatology·Ludovico AbenavoliAngelo Maria Giuffrè
Dec 15, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Agnes PeterfalviLaszlo Szereday
Nov 10, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yuexia ZhangChuan Dong
Aug 5, 2021·Experimental and Therapeutic Medicine·Xing Lu, Fengmei Wang

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