Molecular mechanisms that limit the costs of NLR-mediated resistance in plants

Molecular Plant Pathology
Manon M S RichardValérie Geffroy

Abstract

Crop diseases cause significant yield losses, and the use of resistant cultivars can effectively mitigate these losses and control many plant diseases. Most plant resistance (R) genes encode immune receptors composed of nucleotide-binding and leucine-rich repeat (NLR) domains. These proteins mediate the specific recognition of pathogen avirulence effectors to induce defence responses. However, NLR-triggered immunity can be associated with a reduction in growth and yield, so-called 'fitness costs'. Recent data have shown that plants use an elaborate interplay of different mechanisms to control NLR gene transcript levels, as well as NLR protein abundance and activity, to avoid the associated cost of resistance in the absence of a pathogen. In this review, we discuss the different levels of NLR regulation (transcriptional, post-transcriptional and at the protein level). We address the apparent need for plants to maintain diverse modes of regulation. A recent model suggesting an equilibrium 'ON/OFF state' of NLR proteins, in the absence of a pathogen, provides the context for our discussion.

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Citations

Apr 12, 2020·Cellular and Molecular Life Sciences : CMLS·Hans Thordal-Christensen
Aug 17, 2020·The Journal of Biological Chemistry·Katrina J Linden, Judy Callis
Sep 26, 2019·Journal of Experimental Botany·Gustavo C MacIntosh
Apr 28, 2019·Science China. Life Sciences·Jing WangXuewei Chen
Nov 3, 2020·Frontiers in Genetics·Jia-Yu XueZhu-Qing Shao
May 6, 2021·International Journal of Molecular Sciences·Quang-Minh NguyenSang Hee Kim
Aug 25, 2021·The Plant Journal : for Cell and Molecular Biology·Elisa BellucciRoberto Papa
Aug 30, 2021·The New Phytologist·Adam Hannan ParkerJurriaan Ton

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