Molecular mechanisms underlying calcium current modulation by nociceptin

Neuroreport
Kyu-Young YeonSeog Bae Oh

Abstract

Nociceptin is a non-opioid peptide that modulates pain response. One of mechanism underlying its analgesic action is the inhibition of voltage-dependent calcium current (ICa), similar to that of opioids. We investigated the molecular mechanism by which nociceptin inhibits ICa using sensory neurons and a heterologous expression system. ICa inhibition by nociceptin was voltage-dependent, exhibited the slowing of activation kinetics and prepulse facilitation, and was blocked by N-ethylmaleimide, indicating the involvement of Gi/Go protein. ICa inhibition by nociceptin was primarily mediated through binding to its own receptor, ORL-1, but not through affecting other mu-opioid receptors. Thus, our results strongly demonstrate that heterologous cross-talk between ORL1 and muOR is not involved in the ICa inhibition by nociceptin.

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Citations

Jun 21, 2007·Journal of Neural Transmission·Th Mulder
Aug 31, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Pietro MariniMaura Palmery
Dec 9, 2008·Clinics in Laboratory Medicine·Kristen K ReynoldsSaeed A Jortani
Feb 24, 2006·Journal of Neuroscience Research·Lin PiaoSeog Bae Oh
Jul 26, 2005·Peptides·Richard J Bodnar, Gad E Klein
Jan 3, 2014·Physiological Reviews·Emmanuel BourinetGerald W Zamponi
Jun 7, 2005·The Journal of Pharmacology and Experimental Therapeutics·Victor Ruiz-VelascoAndrew D Sumner
Apr 8, 2020·Acta Neurologica Scandinavica·Gaetano ZaccaraEmilio Russo

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