PMID: 7546403Jun 1, 1995Paper

Molecular mechanisms underlying functional T-cell unresponsiveness

Current Opinion in Immunology
Daniel L Mueller, M K Jenkins

Abstract

Evidence from tissue culture experiments and in vivo studies indicates that certain forms of antigen presentation render T cells unresponsive to subsequent antigenic stimulation. Great progress has been made recently in understanding the induction, maintenance, and in vivo relevance of this unresponsive state, called clonal anergy.

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