Molecular mechanisms underlying hereditary nonpolyposis colorectal carcinoma

Journal of the National Cancer Institute
M S Rhyu

Abstract

MutS and MutL are bacterial genes that have critical roles in DNA repair and recombination. Mutations in homologues of these genes cause hereditary nonpolyposis colorectal carcinoma and are implicated in some sporadic (nonhereditary) colorectal cancers. Molecular functions of these genes have been defined through extensive work in bacteria and yeast. This article reviews and explores molecular events that require MutS and MutL, including mismatch repair, homologous recombination, and gene conversion. The mechanisms of action of eukaryotic MutS and MutL homologues are compared with those of their prokaryotic counterparts, and the relevance of these mechanisms to tumorigenesis is discussed.

Citations

Jan 1, 1997·Genetic Epidemiology·Y Y TsaiF M Giardiello
Jun 17, 2005·Journal of Genetic Counseling·Ann-Marie CodoriMiriam A Tillery
Jan 1, 1997·Cancer Genetics and Cytogenetics·H T LynchJ Lynch
Mar 21, 2000·American Journal of Preventive Medicine·A Y KinneyR S Sandler
Mar 31, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T DebniakJ Lubinski
Feb 27, 2001·Mutation Research·P Peltomäki
Feb 24, 2001·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M Ponz de Leon, A Percesepe
Sep 15, 1998·Pathology International·W H KimJ G Chi
Apr 12, 2007·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Jozef SkardaZdenek Kolar
Jul 16, 2010·Clinical & Developmental Immunology·Kristen M DrescherHenry T Lynch
Mar 24, 1998·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·C N Coleman
Dec 25, 2010·Familial Cancer·Giovanni CorsoFranco Roviello
Nov 16, 2010·Hematology/oncology Clinics of North America·Neel B Shah, Noralane M Lindor
Nov 27, 2008·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Hui ZhangHao Yu
Oct 23, 2002·Pathology, Research and Practice·Erdener OzerMeral Sakizli
Dec 17, 2014·Yonsei Medical Journal·Jeonghyun KangKang Young Lee
Jun 22, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D Scott McMeekinPaul J Goodfellow
Sep 11, 1998·The American Journal of Gastroenterology·A SuspiroF Costa Mira
Sep 21, 2001·Family & Community Health·M B DalyR Bingler
Jul 27, 2000·Annals of the New York Academy of Sciences·C R Boland
Jun 10, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M M de las AlasS B Howell
Apr 3, 1999·International Journal of Cancer. Journal International Du Cancer·M AarnioH J Järvinen
Jul 27, 2005·Biochemical Society Transactions·J M CoxheadJ C Mathers
May 18, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Hong-Wei WuGuang-Hui Wei
Mar 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lainie P MartinRussell J Schilder
Aug 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Han-Shui HsuYi-Ching Wang

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