Molecular Mechanisms Underlying Lymphovascular Invasion in Invasive Breast Cancer

Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology
Mohammed A AleskandaranyEmad A Rakha

Abstract

Lymphovascular invasion (LVI), the presence of malignant cells within lymphovascular channels, is a crucial step in the invasion-metastasis cascade. LVI, when identified morphologically in the peritumoural area, is regarded as an indicator of metastatic potential and is strongly associated with a poor prognosis in many solid tumours, including breast cancer (BC). Although molecular mechanisms associated with the development of LVI have been extensively studied, details of driver genes, and molecular pathways and mechanisms involved in its development in BC, remain poorly defined. Although invasive BC cells have the ability to invade surrounding stroma, only those that can interact with endothelial cells, penetrate the vascular wall and withstand the intravascular stress will develop LVI and complete metastatic dissemination. Identification of additional molecular events associated with LVI in the primary tumour and characterisation of the contribution of the tumour micro-environment to modulating biological processes leading to LVI in BC remain a challenging task. This stems not only from the complexity of the molecular alterations in the primary tumour and the interactions with different components of its micro-environment but...Continue Reading

Citations

Mar 31, 2018·Journal of Clinical Pathology·Emad A RakhaIan O Ellis
Jan 29, 2018·Breast Cancer Research and Treatment·Anne-Sophie HamyFabien Reyal
Feb 19, 2019·Journal of Magnetic Resonance Imaging : JMRI·Zhuangsheng LiuWansheng Long
Apr 9, 2019·Journal of the National Comprehensive Cancer Network : JNCCN·Prashant GabaniImran Zoberi
Aug 23, 2017·British Journal of Cancer·Mohammed A AleskandaranyEmad A Rakha
Oct 11, 2019·Breast Cancer Research and Treatment·Abrar I AljohaniEmad A Rakha
May 23, 2019·British Journal of Cancer·Sasagu KurozumiEmad A Rakha
Apr 11, 2018·Breast Cancer Research and Treatment·Sasagu KurozumiEmad A Rakha
Jun 30, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sultan N SonbulEmad A Rakha
Oct 20, 2020·Breast Cancer Research and Treatment·Yousif A KaririEmad A Rakha
Apr 6, 2021·International Journal of Oral and Maxillofacial Surgery·M MascittiA Santarelli
Jun 4, 2021·Breast Cancer Research and Treatment·Roberta M diFlorio-AlexanderSaeed Hassanpour
Jul 10, 2020·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Yousif A KaririEmad A Rakha

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