Molecular Mechanisms Underlying the Functions of Cellular Markers Associated with the Phenotype of Cancer Stem Cells

Current Stem Cell Research & Therapy
Eduardo Alvarado-OrtizAlejandro García-Carrancá

Abstract

Cancer Stem Cells (CSC) generally constitute a minor cellular population within tumors that exhibits some capacities of normal Stem Cells (SC). The existence of CSC, able to self-renew and differentiate, influences central aspects of tumor biology, in part because they can continue tumor growth, give rise to metastasis, and acquire drug and radioresistance, which open new avenues for therapeutics. It is well known that SC constantly interacts with their niche, which includes mesenchymal cells, extracellular ligands, and the Extra Cellular Matrix (ECM). These interactions regularly lead to homeostasis and maintenance of SC characteristics. However, the exact participation of each of these components for CSC maintenance is not clear, as they appear to be context- or cell-specific. In the recent past, surface cellular markers have been fundamental molecular tools for identifying CSC and distinguishing them from other tumor cells. Importantly, some of these cellular markers have been shown to possess functional roles that affect central aspects of CSC. Likewise, some of these markers can participate in regulating the interaction of CSC with their niche, particularly the ECM. We focused this review on the molecular mechanisms of sur...Continue Reading

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Citations

Jan 8, 2019·World Journal of Stem Cells·Mariel E Toledo-GuzmánElizabeth Ortiz-Sánchez
Aug 9, 2020·Frontiers in Oncology·Miguel Ángel Sarabia-SánchezElizabeth Ortiz-Sánchez
Mar 2, 2021·Frontiers in Cell and Developmental Biology·Eduardo Alvarado-OrtizAlejandro García-Carrancá

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