Molecular Mimicry and Uveitis.

Frontiers in Immunology
Gerhild Wildner, Maria Diedrichs-Möhring

Abstract

Molecular or antigenic mimicry is a term for the similarity of different antigens, which can be confused by the immune system. Antigen recognition by antibodies and T cell receptors is specific, but not restricted to a single antigen. Both types of receptors specifically recognize antigens and are expressed with a very high but still restricted variability compared to the number of different antigens they potentially could bind. T cell receptors only can bind to antigen peptides presented on certain self-MHC-molecules by screening only some amino acid side chains on both the presented peptides and the MHC molecule. The other amino acids of the peptide are not directly perceived by the T cell, offering the opportunity for a single T cell to recognize a variety of different antigens with the same receptor, which significantly increases the immune repertoire. The immune system is usually tolerant to autoantigens, especially to those of immune privileged sites, like the eye. Therefore, autoimmune diseases targeting these organs were hard to explain, unless a T cell is activated by an environmental peptide (e.g. pathogen) that is similar, but not necessarily identical with an autoantigen. Here we describe antigenic mimicry of retina...Continue Reading

References

Jun 1, 1990·Experimental Eye Research·T ShinoharaS Suzuki
Oct 24, 1995·Proceedings of the National Academy of Sciences of the United States of America·S QuaratinoM Londei
Oct 1, 1995·The Journal of Experimental Medicine·J I Elliott, D M Altmann
Oct 1, 1995·Current Opinion in Immunology·C Clayberger, A M Krensky
Sep 1, 1996·European Journal of Immunology·G WildnerS R Thurau
Oct 8, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M B Oldstone
Sep 11, 2002·European Journal of Immunology·Cornelia A DeegBernd Kaspers
Aug 26, 2003·European Journal of Immunology·Gerhild Wildner, Maria Diedrichs-Möhring
May 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nancy A DankeWilliam W Kwok
Aug 4, 2004·Autoimmunity Reviews·Gerhild Wildner, Maria Diedrichs-Möhring
Feb 1, 2005·Annals of the New York Academy of Sciences·Stephan R ThurauGerhild Wildner
Feb 1, 2005·Annals of the New York Academy of Sciences·Gerhild WildnerMaria Diedrichs-Möhring
Jun 15, 2007·Seminars in Immunology·Eric J SundbergRoy A Mariuzza
Jul 11, 2007·The Journal of Experimental Medicine·Harald von Boehmer
Jan 22, 2008·International Immunology·Maria Diedrichs-MöhringGerhild Wildner
Apr 15, 2011·Immunological Reviews·Howard L WeinerHenry Wu
Feb 26, 2013·Nature Reviews. Immunology·Ravid ShechterMichal Schwartz
Jun 4, 2013·Journal of Ophthalmic Inflammation and Infection·Xi K Chu, Chi-Chao Chan
Jul 28, 2016·DNA and Cell Biology·Carlos R Zárate-BladésRachel R Caspi
Feb 2, 2017·Expert Review of Clinical Immunology·Reiko HoraiRachel R Caspi
Oct 29, 2017·Scientific Reports·Valentina VoigtJohn V Forrester
Jan 24, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nathaniel J Schuldt, Bryce A Binstadt

❮ Previous
Next ❯

Citations

Apr 30, 2021·Indian Journal of Ophthalmology·I K KarthikaPriyadarshini Mishra
Jul 7, 2021·Autoimmunity Reviews·Gerhild Wildner

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic

Clinical Trials Mentioned

NCT01195948

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.