PMID: 9532238Apr 9, 1998Paper

Molecular mimicry between cardiac myosin and Trypanosoma cruzi antigen B13: identification of a B13-driven human T cell clone that recognizes cardiac myosin

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
Lucia C J AbelE Cunha Neto

Abstract

Previous reports from our group have demonstrated the association of molecular mimicry between cardiac myosin and the immunodominant Trypanosoma cruzi protein B13 with chronic Chagas' disease cardiomyopathy at both the antibody and heart-infiltrating T cell level. At the peripheral blood level, we observed no difference in primary proliferative responses to T. cruzi B13 protein between chronic Chagas' cardiopathy patients, asymptomatic chagasics and normal individuals. In the present study, we investigated whether T cells sensitized by T. cruzi B13 protein respond to cardiac myosin. T cell clones generated from a B13-stimulated T cell line obtained from peripheral blood of a B13-responsive normal donor were tested for proliferation against B13 protein and human cardiac myosin. The results showed that one clone responded to B13 protein alone and the clone FA46, displaying the highest stimulation index to B13 protein (SI = 25.7), also recognized cardiac myosin. These data show that B13 and cardiac myosin share epitopes at the T cell level and that sensitization of a T cell with B13 protein results in response to cardiac myosin. It can be hypothesized that this also occurs in vivo during T. cruzi infection which results in heart t...Continue Reading

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Citations

Nov 23, 2013·Journal of Cardiovascular Translational Research·Chandirasegaran MassilamanyJay Reddy
Jun 14, 2005·Microbes and Infection·Lúcia C J AbelEdecio Cunha-Neto
Mar 24, 2004·Molecular Immunology·Madeleine W Cunningham
May 9, 2007·Infection and Immunity·Kenneth V HylandDavid M Engman
Jan 1, 2014·Medical Microbiology and Immunology·Miguel Hernán ViccoOscar Bottasso
Apr 30, 2014·Revista Española De Cardiología·Miguel H ViccoOscar A Bottasso
Dec 17, 2008·Clinical and Experimental Immunology·A M Ercolini, S D Miller
Sep 7, 2007·Annals of the New York Academy of Sciences·Núria GironèsManuel Fresno
Oct 21, 2005·Trends in Parasitology·Walderez O DutraMauro M Teixeira
Jul 27, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A L VallochiL V Rizzo
Aug 1, 1998·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·E Cunha-NetoJ Kalil
Dec 29, 2004·Autoimmunity·Denise Golgher, Ricardo T Gazzinelli
Mar 7, 2007·Circulation·Jose Antonio Marin-NetoMarcus V Simões
Feb 4, 2006·Autoimmunity·Edecio Cunha-NetoDavid M Engman

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