Molecular mimicry between non-self, modified self and self in autoimmunity

Seminars in Immunology
A E Karlsen, T Dyrberg

Abstract

Molecular mimicry, the presence of shared epitopes between foreign and self antigens is common both at the B and T cell level. That it only rarely leads to a cross-reactive autoimmune response is a testimony to the effectiveness of the immune system in regulating the immune response and avoiding harmful self-reactivity. However, despite this regulation, various auto-immune-mediated diseases have been associated with molecular mimicry. The concept of molecular mimicry between foreign and self antigen as well as between self and modified self epitopes is reviewed and the relevance of these phenomena for the initiation of autoimmune diseases is discussed.

Citations

Oct 30, 1999·Immunology and Cell Biology·A R Pettit, R Thomas
Sep 17, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Rebecca A Sosa, Thomas G Forsthuber
Apr 16, 2003·Annals of the Rheumatic Diseases·R A Asherson, R Cervera
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·D M Pardoll
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·J DesbaratsM K Newell
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·B ChackerianJ T Schiller
Jul 13, 2000·The New England Journal of Medicine·P J Delves, I M Roitt
Aug 10, 2010·International Journal of Pharmaceutics·Zhenghua ZhongLijuan Chen
Sep 26, 2007·Annals of the New York Academy of Sciences·Philipp von LandenbergKarl J Lackner
Jul 9, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Miri Blank, Yehuda Shoenfeld
Apr 4, 2015·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Pasquale AmbrosinoMatteo Nicola Dario Di Minno
Jul 30, 2005·FEMS Immunology and Medical Microbiology·Kenta WatanabeMasahisa Watarai
Jul 13, 2002·American Journal of Medical Genetics·Flemming Pociot, Allan E Karlsen
Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J Neuberger, R Thomson
Aug 15, 2003·Journal of Peptide Science : an Official Publication of the European Peptide Society·Ross P McGearyIstvan Toth
May 1, 2007·Expert Review of Clinical Immunology·Alexander N KhitrovSergey V Suchkov
Apr 25, 2012·Wiener klinische Wochenschrift·Georgi TchernevCristina Salaro
May 24, 2012·Current Opinion in Rheumatology·Paola Cruz-TapiasYehuda Shoenfeld
Aug 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eduardo ZamoraReinhard Kirnbauer
Jun 12, 2003·International Journal of Immunopathology and Pharmacology·C KonidarisG K Papadopoulos
Oct 22, 2003·Journal of Hepatology·Dimitrios Petrou Bogdanos, Ian G McFarlane

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.