PMID: 8945514Nov 29, 1996Paper

Molecular mimicry in development: identification of ste11+ as a substrate and mei3+ as a pseudosubstrate inhibitor of ran1+ kinase

Cell
P Li, Maureen McLeod

Abstract

ran1+ (pat1+) kinase inhibits exit from the mitotic cell cycle and entry into meiosis. Inactivation of ran1+ by mei3+ is sufficient to precipitate the entire meiotic developmental program. Here, we show that the ste11+ transcription factor is a substrate for ran1+ in vitro and that this reaction is directly inhibited by mei3+. Sequence comparison reveals that ste11+ contains two domains homologous to each other and to a domain of mei3+. Mutagenesis studies reveal that the regions of homology contain substrate specificity determinants. These results identify sequences critical for phosphorylation of ste11+ by ran1+ and suggest that mei3+ employs a pseudosubstrate mechanism for its inhibitory function.

References

Aug 13, 1991·Biochimica Et Biophysica Acta·B E Kemp, R B Pearson
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J D ScottE G Krebs
Sep 1, 1974·Experimental Cell Research·R Egel, M Egel-Mitani
Sep 1, 1995·Molecular and Cellular Biology·M WillerO Nielsen
Feb 1, 1993·Trends in Cell Biology·O Nielsen
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·Y Iino, M Yamamoto
Jan 1, 1985·Molecular & General Genetics : MGG·Y Lino, M Yamamoto

❮ Previous
Next ❯

Citations

Aug 4, 2007·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Yuriko Harigaya, Masayuki Yamamoto
Nov 20, 2013·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Edwige Hiriart, André Verdel
Dec 2, 2004·Nature Reviews. Molecular Cell Biology·Adèle L Marston, Angelika Amon
Jun 1, 1997·Molecular Biology of the Cell·M CaligiuriD Beach
Dec 15, 2010·Molecular Biology of the Cell·Nicole CremonaJo Ann Wise
Nov 16, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Folkert J van Werven, Angelika Amon
Jan 29, 2000·Molecular and Cellular Biology·S Shinozaki-YabanaM Yamamoto
Jan 28, 2004·Bioscience, Biotechnology, and Biochemistry·Kaori TanabeMakoto Kawamukai
Jan 19, 2012·PloS One·Ana M Matia-GonzalezMiguel A Rodriguez-Gabriel
Oct 16, 2010·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Masayuki Yamamoto
Dec 22, 2011·Molecular Systems Biology·Danny A BittonCrispin J Miller
Feb 19, 2002·Fungal Genetics and Biology : FG & B·Jon P Woods
Jan 13, 1999·Yeast·J Davey
Nov 1, 2017·Journal of Cell Science·Francisco J NavarroPaul Nurse
Jul 17, 2009·Critical Reviews in Biochemistry and Molecular Biology·Katrien Van Der KelenLieven De Veylder
Feb 18, 2003·Molecular Genetics and Genomics : MGG·E Asp, P Sunnerhagen
Feb 3, 1998·Molecular and Cellular Biology·N OkazakiH Okayama
Nov 20, 1998·Molecular and Cellular Biology·W J Van HeeckerenK Struhl
Jul 22, 1998·Molecular and Cellular Biology·K TsukaharaH Okayama
Jul 3, 2020·Genes·Anne M MacKenzie, Soni Lacefield
Nov 22, 2013·Biochemical Society Transactions·Jayamani AnandhakumarDamien Hermand
Jan 11, 2018·Scientific Reports·Tanvi BholaP K Vinod
Jul 25, 2017·Cold Spring Harbor Protocols·Akira YamashitaMasayuki Yamamoto

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell eTOC

Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.