Molecular models for shikimate pathway enzymes of Xylella fastidiosa

Biochemical and Biophysical Research Communications
Helen Andrade ArcuriWalter Filgueira de Azevedo Júnior

Abstract

The Xylella fastidiosa is a bacterium that is the cause of citrus variegated chlorosis (CVC). The shikimate pathway is of pivotal importance for production of a plethora of aromatic compounds in plants, bacteria, and fungi. Putative structural differences in the enzymes from the shikimate pathway, between the proteins of bacterial origin and those of plants, could be used for the development of a drug for the control of CVC. However, inhibitors for shikimate pathway enzymes should have high specificity for X. fastidiosa enzymes, since they are also present in plants. In order to pave the way for structural and functional efforts towards antimicrobial agent development, here we describe the molecular modeling of seven enzymes of the shikimate pathway of X. fastidiosa. The structural models of shikimate pathway enzymes, complexed with inhibitors, strongly indicate that the previously identified inhibitors may also inhibit the X. fastidiosa enzymes.

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Citations

Mar 11, 2005·Journal of Molecular Modeling·Nelson José Freitas da SilveiraWalter Filgueira de Azevedo
Dec 2, 2008·Journal of Molecular Modeling·Guy Barros BarcellosWalter Filgueira de Azevedo
Feb 14, 2012·Journal of Plant Physiology·Debabrata SircarBirgit Arnholdt-Schmitt
Oct 12, 2004·Biochemical and Biophysical Research Communications·Fernanda CanduriWalter Filgueira de Azevedo
Aug 30, 2005·Current Opinion in Microbiology·João C SetubalAna C R da Silva
Jun 5, 2020·Journal of Experimental Botany·Jun ChenHongwei Cai

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