Molecular motions in supercooled and glassy ibuprofen: deuteron magnetic resonance and high-resolution rheology study

The Journal of Physical Chemistry. B
S BauerR Böhmer

Abstract

Using deuteron nuclear magnetic resonance, the molecular motions of specifically isotope-labeled ibuprofen were probed at the carboxylic group and at the methin group next to it. Spin relaxometry revealed slight differences between the molecular motions of the two isotopomers that are rationalized with reference to the hydrogen bonding of the COOH moiety. In the glassy state, a small-angle jump process among about four sites, related to the so-called γ-process, was identified using stimulated-echo spectroscopy. Indications for a Debye-like process, previously found to leave a weak signature in the dielectric loss, could not unambiguously be detected in magnetic resonance or shear mechanical experiments carried out for supercooled liquid ibuprofen.

References

Feb 21, 1998·Journal of Magnetic Resonance·B GeilH Sillescu
Jul 23, 2004·The Journal of Chemical Physics·K L Ngai, M Paluch
Aug 20, 2005·The Journal of Chemical Physics·Li-Min Wang, Ranko Richert
Dec 15, 2006·The Journal of Chemical Physics·K SchröterG B McKenna
Jun 20, 2008·Pharmaceutical Research·Emeline DudognonNatália T Correia
Aug 9, 2008·The Journal of Physical Chemistry. B·Ana R BrásNatália T Correia
Nov 18, 2009·The Journal of Chemical Physics·Catalin GainaruRoland Böhmer
Jan 27, 2010·Acta Crystallographica. Section B, Structural Science·Patrick DerollezMarc Descamps
Apr 27, 2010·The Journal of Physical Chemistry. B·K AdrjanowiczW Sawicki
Aug 17, 2010·The Journal of Physical Chemistry. B·F Affouard, Natália T Correia
Mar 8, 2011·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Elisa CarignaniMarco Geppi
Apr 5, 2011·The Journal of Physical Chemistry. B·K AdrjanowiczJ Pionteck
Jul 13, 2011·The Journal of Physical Chemistry. a·Elisa CarignaniMarco Geppi
Oct 1, 2011·International Journal of Pharmaceutics·Alain HédouxNatalia T Correia
Aug 11, 2012·Pharmaceutical Research·Emeline DudognonMarc Descamps
Mar 26, 2013·Physical Chemistry Chemical Physics : PCCP·H NelsonR Böhmer
Apr 9, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·U SailajaG Govindaraj
Oct 15, 2013·The Journal of Chemical Physics·S BauerR Böhmer
Nov 13, 2013·Molecular Pharmaceutics·A C RodriguesN T Correia
Jul 16, 2014·The Journal of Physical Chemistry. B·Philip J GriffinJoshua R Sangoro

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.