Molecular MR-Imaging for Noninvasive Quantification of the Anti-Inflammatory Effect of Targeting Interleukin-1β in a Mouse Model of Aortic Aneurysm.

Molecular Imaging
Julia BrangschMarcus R Makowski

Abstract

Molecular-MRI is a promising imaging modality for the assessment of abdominal aortic aneurysms (AAAs). Interleukin-1β (IL-1β) represents a new therapeutic tool for AAA-treatment, since pro-inflammatory cytokines are key-mediators of inflammation. This study investigates the potential of molecular-MRI to evaluate therapeutic effects of an anti-IL-1β-therapy on AAA-formation in a mouse-model. Osmotic-minipumps were implanted in apolipoprotein-deficient-mice (N = 27). One group (Ang-II+01BSUR group, n = 9) was infused with angiotensin-II (Ang-II) for 4 weeks and received an anti-murine IL-1β-antibody (01BSUR) 3 times. One group (Ang-II-group, n = 9) was infused with Ang-II for 4 weeks but received no treatment. Control-group (n = 9) was infused with saline and received no treatment. MR-imaging was performed using an elastin-specific gadolinium-based-probe (0.2 mmol/kg). Mice of the Ang-II+01BSUR-group showed a lower aortic-diameter compared to mice of the Ang-II-group and control mice (p < 0.05). Using the elastin-specific-probe, a significant decrease in elastin-destruction was observed in mice of the Ang-II+01BSUR-group. In vivo MR-measurements correlated well with histopathology (y = 0.34x-13.81, R2 = 0.84, p < 0.05), ICP-MS (y...Continue Reading

References

May 1, 1991·Annals of Vascular Surgery·C M BrophyM D Tilson
Aug 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·T FreestoneJ T Powell
Dec 31, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·J JuvonenT Juvonen
Jun 7, 2000·The Journal of Clinical Investigation·A DaughertyL A Cassis
Apr 5, 2002·Current Atherosclerosis Reports·Alan Daugherty, Lisa A Cassis
Jan 24, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Alan Daugherty, Lisa A Cassis
May 4, 2005·Lancet·N SakalihasanO D Defawe
Feb 25, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Koichi ShimizuPeter Libby
Dec 3, 2008·Circulation·Jonathan GolledgePaul E Norman
Mar 3, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Lisa A CassisAlan Daugherty
May 27, 2009·Nature Reviews. Cardiology·Femke A M V I HellenthalGeert Willem H Schurink
Jul 25, 2009·Journal of Magnetic Resonance Imaging : JMRI·Gregory H TurnerBeat M Jucker
Feb 26, 2010·Current Vascular Pharmacology·Hao HongWeibo Cai
Feb 10, 2011·Circulation. Cardiovascular Imaging·Jennifer M J RichardsDavid E Newby
Mar 8, 2011·Circulation. Cardiovascular Imaging·Christian von BaryRené Botnar
Apr 28, 2011·European Journal of Immunology·Charles A Dinarello
Jan 5, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·William F JohnstonGorav Ailawadi
May 30, 2014·Circulation. Cardiovascular Imaging·René M BotnarMarcus R Makowski
Aug 29, 2017·The New England Journal of Medicine·Paul M RidkerUNKNOWN CANTOS Trial Group
Jun 10, 2018·International Journal of Cardiology·Kikuo IsodaHiroyuki Daida
Feb 1, 2019·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
May 28, 2019·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Yoshiaki HashimotoYasuhiko Itoh

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Citations

Apr 4, 2021·International Journal of Molecular Sciences·Lisa AdamsSarah Keller

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Methods Mentioned

BETA
dissection

Software Mentioned

01BSUR
OsiriX
ImageJ

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