Molecular networks in skeletal muscle plasticity

The Journal of Experimental Biology
H Hoppeler

Abstract

The skeletal muscle phenotype is subject to considerable malleability depending on use as well as internal and external cues. In humans, low-load endurance-type exercise leads to qualitative changes of muscle tissue characterized by an increase in structures supporting oxygen delivery and consumption, such as capillaries and mitochondria. High-load strength-type exercise leads to growth of muscle fibers dominated by an increase in contractile proteins. In endurance exercise, stress-induced signaling leads to transcriptional upregulation of genes, with Ca(2+) signaling and the energy status of the muscle cells sensed through AMPK being major input determinants. Several interrelated signaling pathways converge on the transcriptional co-activator PGC-1α, perceived to be the coordinator of much of the transcriptional and post-transcriptional processes. Strength training is dominated by a translational upregulation controlled by mTORC1. mTORC1 is mainly regulated by an insulin- and/or growth-factor-dependent signaling cascade as well as mechanical and nutritional cues. Muscle growth is further supported by DNA recruitment through activation and incorporation of satellite cells. In addition, there are several negative regulators of m...Continue Reading

References

Jun 1, 1990·Journal of Applied Physiology·N TerradosL Kaijser
Jun 1, 1986·International Journal of Sports Medicine·J M LüthiH Hoppeler
Aug 1, 1986·International Journal of Sports Medicine·H Hoppeler
May 1, 1985·Pflügers Archiv : European journal of physiology·H ReichmannD Pette
Aug 1, 1985·Journal of Applied Physiology·H HoppelerE R Weibel
Sep 1, 1967·The American Journal of Physiology·P K Pattengale, J O Holloszy
Jan 1, 1982·Cell and Tissue Research·K S BuserH Hoppeler
Sep 1, 1995·The American Journal of Physiology·A PuntschartR Billeter
Dec 1, 1994·Journal of Applied Physiology·T W Balon, J L Nadler
Dec 10, 1997·International Journal of Sports Medicine·D Desplanches
Jul 11, 2001·Experimental Physiology·J S LeeJ A Hawley
Oct 19, 2001·European Journal of Applied Physiology·K MasudaS Katsuta
Sep 19, 2002·The Journal of Biological Chemistry·Julie St-PierreMartin D Brand
Feb 4, 2003·The Journal of Physiology·Henriette PilegaardP Darrell Neufer
Feb 28, 2003·Reviews of Physiology, Biochemistry and Pharmacology·M Flück, H Hoppeler
Jun 5, 2003·Medicine and Science in Sports and Exercise·Michael VogtHans Hoppeler
Aug 5, 2003·European Journal of Applied Physiology·Hans Howald, Hans Hoppeler
Sep 16, 2003·Journal of Applied Physiology·Jessica NorrbomThomas Gustafsson
Jul 1, 1956·Physiological Reviews·P O ASTRAND
Jun 26, 2004·The Journal of Physiology·Fawzi KadiJesper L Andersen
Jun 4, 2005·The Journal of Physiology·Mari-Carmen Gomez-CabreraJose Viña
May 18, 2006·The Journal of Clinical Endocrinology and Metabolism·Indrani Sinha-HikimShalender Bhasin
Sep 15, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Steven D MasonRandall S Johnson
Jan 15, 2008·Pflügers Archiv : European journal of physiology·François B FavierDamien Freyssenet
Feb 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Andrew M BellingerAndrew R Marks
Sep 9, 2008·Scandinavian Journal of Medicine & Science in Sports·H HoppelerM Vogt
Dec 26, 2008·Methods in Molecular Biology·Jenifer C Croce, David R McClay
Feb 26, 2009·Nutrition Reviews·John A Hawley, John O Holloszy
Mar 19, 2009·European Journal of Applied Physiology·Stephan KlossnerMartin Flueck
May 19, 2009·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Stuart M Phillips
Dec 22, 2009·Sports Medicine·Gregoire P MilletJ P Richalet
Mar 19, 2011·Current Opinion in Clinical Nutrition and Metabolic Care·Sjoerd A A van den BergPatrick Schrauwen
Feb 15, 2012·Medicine and Science in Sports and Exercise·Hermann Zbinden-FonceaMarc Francaux
Feb 23, 2012·American Journal of Physiology. Endocrinology and Metabolism·Kayleigh M Dodd, Andrew R Tee
Jan 11, 2013·Physiological Reviews·Hang YinMichael A Rudnicki
Feb 15, 2013·The Journal of Experimental Biology·Liam P McGuireChristopher G Guglielmo
May 23, 2013·American Journal of Physiology. Endocrinology and Metabolism·Hannah CrosslandPhilip J Atherton
May 28, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Birgitte HoierYlva Hellsten
May 30, 2013·PloS One·Chia Yee Tan, Thilo Hagen

❮ Previous
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Citations

May 29, 2016·The Journal of Physiology·Mark A SarzynskiClaude Bouchard
Mar 1, 2017·Cold Spring Harbor Perspectives in Medicine·Barbara KuprChristoph Handschin
Mar 22, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Xiaolei ZhangPaul M Coen
Jan 23, 2016·The Journal of Experimental Biology·William J SmilesDonny M Camera
Jul 8, 2018·The Journal of Experimental Biology·Jason TallisFrank Seebacher
May 22, 2018·Journal of Strength and Conditioning Research·David Rodríguez-RosellJuan J González-Badillo
Jul 15, 2018·Human Molecular Genetics·Fatima-Zohra BoufrouraFatima Djouadi
Apr 5, 2019·Journal of Applied Physiology·Kleiton Augusto Santos SilvaTadashi Yoshida
Jan 23, 2020·Journal of Cellular Physiology·Thomas BeiterDirk Moser
Feb 6, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·David Rodríguez-RosellJuan José González-Badillo
Jun 3, 2020·Integrative and Comparative Biology·Alexander A Mauro, Cameron K Ghalambor
Feb 20, 2019·Sports Medicine·Manuel WidmannBarbara Munz
Apr 4, 2020·Canadian Journal of Physiology and Pharmacology·João Victor Capelli PeixotoFernando Augusto Lavezzo Dias
Jun 10, 2017·Frontiers in Physiology·Peter Hofmann, Gerhard Tschakert
Apr 5, 2018·Frontiers in Neuroscience·Yury Ivanenko, Victor S Gurfinkel
Dec 13, 2018·European Journal of Applied Physiology·Ashraf S GorgeyZachary A Graham
Oct 9, 2018·European Journal of Sport Science·Barbara WessnerRobert Csapo
Jul 23, 2020·Nature Metabolism·Katja A Lamia
Jul 5, 2016·Expert Review of Proteomics·Paul DowlingKay Ohlendieck
Oct 7, 2018·Pflügers Archiv : European journal of physiology·Steven Carter, Thomas P J Solomon
Dec 3, 2016·Frontiers in Physiology·Hans Hoppeler
Oct 3, 2018·Nutrition & Metabolism·Oak-Kee HongSoon Jib Yoo
Sep 19, 2019·Journal of Physical Activity & Health·Bruno P MeloSolange M Franzói de Moraes
Nov 2, 2018·The Journal of Experimental Biology·Hans Hoppeler
Oct 9, 2020·The American Journal of Sports Medicine·Brady GreenTania Pizzari

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