PMID: 9427013Jan 14, 1998Paper

Molecular neurobiology of Alzheimer's disease (syndrome?)

Harvard Review of Psychiatry
G S Zubenko

Abstract

Alzheimer's disease (AD) is the most common cause of mental impairment in late life and is estimated to afflict nearly half of older adults who live beyond age 85. Although progressive dementia is a cardinal feature of patients with AD, age at symptomatic onset, rate of progression, and specific signs and symptoms vary widely. This clinical heterogeneity appears to arise in part from interindividual differences in the precise molecular events that contribute to the pathophysiology of AD, as well as from nonuniform or multifocal patterns of brain degeneration that occur during the early to middle stages of dementia. The goals of this review are to cover the substantial progress that has been made over the past 5 years in the major thematic areas of research in AD and to assemble these individual findings into a more integrated picture of the pathophysiology of the disorder. The results may have important implications for the treatment or prevention of AD.

Citations

Sep 6, 2008·Analytical and Bioanalytical Chemistry·Tatyana V BarkhimerL M Viranga Tillekeratne
Apr 3, 1999·Biological Psychiatry·G S ZubenkoA J Martinez
Jul 27, 1999·Biological Psychiatry·G S ZubenkoJ S Stiffler
Feb 5, 2014·FEBS Letters·Pierpaolo SorrentinoGiuseppe Sorrentino
Apr 2, 2002·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Jason T OlinBarry D Lebowitz
Feb 25, 2009·Annals of the New York Academy of Sciences·Alfred Sholl-FrancoJuliana Adão-Novaes
Jul 11, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·George S ZubenkoWendy N Zubenko
Jul 26, 2014·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·George S ZubenkoBruce M Cohen
Sep 24, 1999·Biological Psychiatry·G S ZubenkoJ S Stiffler
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Reem A MohamedHanan S El-Abhar

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