Dec 31, 2016

Molecular Neuroimaging in Posttraumatic Stress Disorder

Experimental Neurobiology
Jooyeon Jamie ImSujung Yoon

Abstract

Over the past decade, an increasing number of neuroimaging studies have provided insight into the neurobiological mechanisms of posttraumatic stress disorder (PSTD). In particular, molecular neuroimaging techniques have been employed in examining metabolic and neurochemical processes in PTSD. This article reviews molecular neuroimaging studies in PTSD and focuses on findings using three imaging modalities including positron emission tomography (PET), single photon emission computed tomography (SPECT), and magnetic resonance spectroscopy (MRS). Although there were some inconsistences in the findings, patients with PTSD showed altered cerebral metabolism and perfusion, receptor bindings, and metabolite profiles in the limbic regions, medial prefrontal cortex, and temporal cortex. Studies that have investigated brain correlates of treatment response are also reviewed. Lastly, the limitations of the molecular neuroimaging studies and potential future research directions are discussed.

  • References63
  • Citations3

References

Mentioned in this Paper

Metabolic Process, Cellular
Study
Research
Adrenal Cortex Diseases
Tomography, Emission-Computed, Single-Photon
Positron-Emission Tomography
Brain
Post-Traumatic Stress Disorder
Metabolic Pathway
Neurobiology

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