PMID: 9440021Jan 24, 1998Paper

Molecular neuropathology of astrocytic brain tumors

Journal of Neuro-oncology
T Pietsch, O D Wiestler

Abstract

Both surgical and molecular neuropathologists have recently achieved remarkable progress in the histogenetic classification and molecular characterization of human gliomas. Major histopathological achievements in the revised WHO classification include the introduction of immunohistochemical reagents for glial fibrillary acidic protein and for the proliferation-associated antigens, the definition of glioblastoma multiforme as an astrocytic neoplasm and the recognition of the pleomorphic xantho--astrocytomas as a novel clinico-pathological entity. In molecular neuropathology, alterations of oncogenes and tumor suppressor genes and their potential functions have been identified, microsatellite analyses have revealed novel loci for putative tumor suppressor genes and distinct molecular pathways for different tumor entities are beginning to emerge. Mutations in cell cycle regulatory genes are present in most glioblastomas and may account for their striking growth potential. Autocrine and paracrine growth factors and their respective protein tyrosine kinase receptors appear to contribute both to glial and endothelial cell proliferation. In our contribution, we would like to focus on astrocytic gliomas. Findings with potential diagnos...Continue Reading

Citations

Nov 24, 2004·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Peiyu PuHao Jiang
Dec 9, 2008·Journal of Neurosurgery·Goetz LuetjensJoachim K Krauss
Jan 22, 2011·Journal of Neurosurgery·Bo WuJinping Liu
Sep 1, 2003·Expert Review of Neurotherapeutics·Gustavo PradillaHenry Brem
Dec 1, 2007·Expert Opinion on Medical Diagnostics·Fatima W Khwaja
May 18, 1999·Current Opinion in Oncology·A Weyerbrock, E H Oldfield
Mar 2, 2011·Arquivos de neuro-psiquiatria·Alexandre M CunhaJorge P B M Souza
Nov 26, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R H GoldbrunnerJ C Tonn
Apr 23, 2004·Current Neurology and Neuroscience Reports·Lynn S Ashby, William R Shapiro
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Oct 7, 2004·Cancer Research·Hiroko OhgakiPaul Kleihues
Jun 7, 2011·Life Sciences·Tercia Rodrigues AlvesVivaldo Moura Neto

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