PMID: 6540314Jul 15, 1984Paper

Molecular organization of paramyosin in the core of molluscan thick filaments

Journal of Molecular Biology
A Elliott, P M Bennett

Abstract

An arrangement of paramyosin molecules in the polar part of molluscan thick filaments is proposed which accounts for the X-ray diffraction pattern of the smooth adductor muscle (other than the part ascribed to actin) and for the appearance of separated filaments in the electron microscope. The proposed structure is based on the PI arrangement of Cohen et al. (1971), and contains sets of parallel, equidistant molecules with successive molecules displaced along the molecular axis by 72 nm, which we call PI sheets. Every molecule belongs to two PI sheets which are nearly perpendicular. This array is not propagated throughout the filament, but is sheared periodically in the direction of the molecular (filament) axis by 2/5 X 72 nm. The shear occurs along parallel equidistant planes which are inclined to the PI sheets. The analysis of the X-ray data has been made possible by concentrating on those patterns from filaments in which the two sets of PI sheets appear to be mutually perpendicular, a condition brought about by bathing the muscle in aqueous acetone. In one set, there are four intermolecular spaces between shear planes (this appears to be true at least for the smooth adductors of Ostrea edulis, Crassostrea angulata and Merce...Continue Reading

References

Aug 15, 1979·Journal of Molecular Biology·A Elliott
Mar 25, 1975·Journal of Molecular Biology·W Longley
Oct 28, 1970·Journal of Molecular Biology·A Elliott, J Lowy
Mar 14, 1971·Journal of Molecular Biology·C CohenJ Kendrick-Jones
May 18, 1968·Nature·A ElliottP J Vibert
May 5, 1984·Journal of Molecular Biology·P M Bennett, A Elliott
Feb 25, 1981·Journal of Molecular Biology·P M Bennett
Jan 1, 1982·General Pharmacology·R C Elliott
Jan 25, 1956·The Journal of Biophysical and Biochemical Cytology·R S BEAR, C C SELBY
Nov 23, 1957·Nature·J HANSONJ C RUEGG
May 1, 1963·Journal of Molecular Biology·C COHEN, K C HOLMES
Sep 1, 1963·Journal of Molecular Biology·S LOWEYA HOLTZER
Oct 1, 1952·Proceedings of the National Academy of Sciences of the United States of America·A J Hodge

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Citations

Jan 1, 1990·Tissue & Cell·S Hunt, A El Sherief
Jan 1, 1988·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·C Cohen, L Castellani
May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·C Cohen
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L Castellani, C Cohen
Aug 1, 1988·Journal of Electron Microscopy Technique·M Stewart
Jul 17, 2013·Journal of Muscle Research and Cell Motility·John M Squire
Feb 1, 1989·Journal of Muscle Research and Cell Motility·R Ward, P M Bennett
Oct 1, 1990·Journal of Muscle Research and Cell Motility·R Ward, J M Murray
Apr 1, 1992·Journal of Muscle Research and Cell Motility·L Castellani, P Vibert
Sep 1, 2009·Biophysics Reviews·John M Squire

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